Monitoring the elimination of gambiense human African trypanosomiasis in the historical focus of Batie, South-West Burkina Faso

Compaore, Charlie Franck Alfred, Kabore, Jacques, Ilboudo, Hamidou, Thomas, Lian Francesca ORCID: 0000-0001-8447-1210, Falzon, Laura Cristina, Bamba, Mohamed, Sakande, Hassane, Kone, Minayegninrin, Kaba, Dramane, Bougouma, Clarisse
et al (show 7 more authors) (2022) Monitoring the elimination of gambiense human African trypanosomiasis in the historical focus of Batie, South-West Burkina Faso. PARASITE, 29. 25-.

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The World Health Organisation has targeted the elimination of human African trypanosomiasis (HAT) as zero transmission by 2030. Continued surveillance needs to be in place for early detection of re-emergent cases. In this context, the performance of diagnostic tests and testing algorithms for detection of the re-emergence of Trypanosoma brucei gambiense HAT remains to be assessed. We carried out a door-to-door active medical survey for HAT in the historical focus of Batié, South-West Burkina Faso. Screening was done using three rapid diagnostic tests (RDTs). Two laboratory tests (ELISA/T. b. gambiense and immune trypanolysis) and parasitological examination were performed on RDT positives only. In total, 5883 participants were screened, among which 842 (14%) tested positive in at least one RDT. Blood from 519 RDT positives was examined microscopically but no trypanosomes were observed. The HAT Sero-K-Set test showed the lowest specificity of 89%, while the specificities of SD Bioline HAT and rHAT Sero-Strip were 92% and 99%, respectively. The specificity of ELISA/T. b. gambiense and trypanolysis was 99% (98-99%) and 100% (99-100%), respectively. Our results suggest that T. b. gambiense is no longer circulating in the study area and that zero transmission has probably been attained. While a least cost analysis is still required, our study showed that RDT preselection followed by trypanolysis may be a useful strategy for post-elimination surveillance in Burkina Faso.

Item Type: Article
Uncontrolled Keywords: Human African trypanosomiasis, Trypanosoma brucei gambiense, Elimination, Diagnosis, Rapid diagnostic test, Specificity, Dried blood spot, Burkina Faso
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences
Depositing User: Symplectic Admin
Date Deposited: 18 May 2022 13:51
Last Modified: 18 Jan 2023 21:02
DOI: 10.1051/parasite/2022024
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