Incidence of non-typhoidal Salmonella invasive disease: A systematic review and meta-analysis.

Marchello, Christian S, Fiorino, Fabio ORCID: 0000-0002-1440-8061, Pettini, Elena, Crump, John A and Vacc-iNTS Consortium Collaborators,
(2021) Incidence of non-typhoidal Salmonella invasive disease: A systematic review and meta-analysis. The Journal of infection, 83 (5). pp. 523-532.

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<h4>Objectives</h4>We sought to collate and summarize high-quality data on non-typhoidal Salmonella invasive disease (iNTS) incidence to provide contemporary incidence estimates by location and year.<h4>Methods</h4>We systematically searched the databases Embase + MEDLINE, Web of Science, and PubMed for articles published on the incidence of iNTS from inception of the database through 8 May 2020 with no language, country, date, or demographic restrictions applied. A meta-analysis was performed to report pooled iNTS incidence as a rate of cases per 100,000 per year.<h4>Results</h4>Among 13 studies eligible for analysis, there were 68 estimates of incidence. Overall pooled incidence (95% CI) was 44.8 (31.5-60.5) per 100,000 persons per year. When stratified by region, pooled incidence was significantly higher in Africa than Asia, 51.0 (36.3-68.0) compared to 1.0 (0.2-2.5), respectively. Incidence was consistently higher in children aged <5 years compared with older age groups. Incidence displayed considerable heterogeneity in both place and time, varying substantially between locations and over consecutive years in the same location.<h4>Conclusions</h4>iNTS incidence varies by region, location, age group, and over time. Concerted efforts are needed to address the limited high-quality data available on iNTS disease incidence.

Item Type: Article
Uncontrolled Keywords: Vacc-iNTS Consortium Collaborators, Humans, Salmonella, Salmonella Infections, Incidence, Aged, Child, Africa, Asia
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences
Depositing User: Symplectic Admin
Date Deposited: 19 May 2022 09:14
Last Modified: 18 Jan 2023 21:01
DOI: 10.1016/j.jinf.2021.06.029
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