Risk factors associated with short-term mortality and recurrence of status epilepticus in dogs



Fentem, Rory ORCID: 0000-0001-5094-7831, de Stefani, Alberta, Quintana, Rodrigo Gutierrez, Alcoverro, Emili, Jones, Gareth Michael Couper, Amengual-Batle, Pablo and Goncalves, Rita ORCID: 0000-0001-5420-9801
(2022) Risk factors associated with short-term mortality and recurrence of status epilepticus in dogs. JOURNAL OF VETERINARY INTERNAL MEDICINE, 36 (2). pp. 656-662.

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Abstract

<h4>Background</h4>Status epilepticus (SE) is an emergency associated with serious consequences for both patient and owner. Data regarding risk factors for short-term mortality or recurrence in dogs with SE is limited.<h4>Objective</h4>Identify risk factors associated with short-term mortality (euthanasia or spontaneous death) and recurrence of SE in dogs.<h4>Animals</h4>One hundred twenty-four client-owned dogs that sustained an episode of SE.<h4>Methods</h4>Retrospective multicenter study using data collected from medical records of dogs presented in SE to the contributing institutions. Multivariable logistic regression analysis was performed using a manual backwards stepwise approach to identify risk factors associated with short-term mortality and recurrence of SE after discharge.<h4>Results</h4>Short-term mortality for affected dogs was 29.8%. Factors significantly associated with short-term mortality included increased patient age, shorter duration of hospitalization, development of SE before arrival, and SE caused by a potentially fatal etiology. Status epilepticus recurred in 27% of dogs that survived to discharge. Factors significantly associated with recurrence of SE included prior history of pharmacoresistant epilepsy and predominance of a focal seizure phenotype.<h4>Conclusions and clinical importance</h4>Our results may be used to inform clinicians and dog owners regarding risk factors for both short-term mortality and recurrence in dogs with SE.

Item Type: Article
Uncontrolled Keywords: canine, epilepsy, outcome, seizures
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences
Depositing User: Symplectic Admin
Date Deposited: 19 May 2022 09:55
Last Modified: 18 Jan 2023 21:01
DOI: 10.1111/jvim.16353
Open Access URL: https://doi.org/10.1111/jvim.16353
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URI: https://livrepository.liverpool.ac.uk/id/eprint/3155138