Risk factors associated with short-term mortality and recurrence of status epilepticus in dogs

Fentem, Rory ORCID: 0000-0001-5094-7831, de Stefani, Alberta, Quintana, Rodrigo Gutierrez, Alcoverro, Emili, Jones, Gareth Michael Couper, Amengual-Batle, Pablo and Goncalves, Rita ORCID: 0000-0001-5420-9801 (2022) Risk factors associated with short-term mortality and recurrence of status epilepticus in dogs JOURNAL OF VETERINARY INTERNAL MEDICINE, 36 (2). pp. 656-662. ISSN 0891-6640, 1939-1676

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Abstract

Background: Status epilepticus (SE) is an emergency associated with serious consequences for both patient and owner. Data regarding risk factors for short-term mortality or recurrence in dogs with SE is limited. Objective: Identify risk factors associated with short-term mortality (euthanasia or spontaneous death) and recurrence of SE in dogs. Animals: One hundred twenty-four client-owned dogs that sustained an episode of SE. Methods: Retrospective multicenter study using data collected from medical records of dogs presented in SE to the contributing institutions. Multivariable logistic regression analysis was performed using a manual backwards stepwise approach to identify risk factors associated with short-term mortality and recurrence of SE after discharge. Results: Short-term mortality for affected dogs was 29.8%. Factors significantly associated with short-term mortality included increased patient age, shorter duration of hospitalization, development of SE before arrival, and SE caused by a potentially fatal etiology. Status epilepticus recurred in 27% of dogs that survived to discharge. Factors significantly associated with recurrence of SE included prior history of pharmacoresistant epilepsy and predominance of a focal seizure phenotype. Conclusions and Clinical Importance: Our results may be used to inform clinicians and dog owners regarding risk factors for both short-term mortality and recurrence in dogs with SE.

Item Type:	Article
Uncontrolled Keywords:	canine, epilepsy, outcome, seizures
Divisions:	Faculty of Health & Life Sciences Faculty of Health & Life Sciences > Inst. Infection, Vet & Ecological Sciences
Depositing User:	Symplectic Admin
Date Deposited:	19 May 2022 09:55
Last Modified:	22 Jan 2026 04:02
DOI:	10.1111/jvim.16353
Open Access URL:	https://doi.org/10.1111/jvim.16353
Related Websites:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3155138
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