Shenoy, U Sangeetha, Adiga, Divya, Kabekkodu, Shama Prasada, Hunter, Keith D 
ORCID: 0000-0002-7873-0877 and Radhakrishnan, Raghu
(2021)
Molecular implications of HOX genes targeting multiple signaling pathways in cancer.
Cell biology and toxicology, 38 (1).
pp. 1-30.
Abstract
Homeobox (HOX) genes encode highly conserved homeotic transcription factors that play a crucial role in organogenesis and tissue homeostasis. Their deregulation impacts the function of several regulatory molecules contributing to tumor initiation and progression. A functional bridge exists between altered gene expression of individual HOX genes and tumorigenesis. This review focuses on how deregulation in the HOX-associated signaling pathways contributes to the metastatic progression in cancer. We discuss their functional significance, clinical implications and ascertain their role as a diagnostic and prognostic biomarker in the various cancer types. Besides, the mechanism of understanding the theoretical underpinning that affects HOX-mediated therapy resistance in cancers has been outlined. The knowledge gained shall pave the way for newer insights into the treatment of cancer.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HOX genes, Diagnostic and prognostic significance, Signaling pathways, Metastasis, Cancer |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 24 May 2022 08:16 |
| Last Modified: | 05 May 2023 10:55 |
| DOI: | 10.1007/s10565-021-09657-2 |
| Open Access URL: | https://doi.org/10.1007/s10565-021-09657-2 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3155385 |
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