Worked to the bone: antibody-based conditioning as the future of transplant biology

Griffin, James M, Healy, Fiona M, Dahal, Lekh N, Floisand, Yngvar and Woolley, John F ORCID: 0000-0001-7885-8515
(2022) Worked to the bone: antibody-based conditioning as the future of transplant biology. JOURNAL OF HEMATOLOGY & ONCOLOGY, 15 (1). 65-.

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Conditioning of the bone marrow prior to haematopoietic stem cell transplant is essential in eradicating the primary cause of disease, facilitating donor cell engraftment and avoiding transplant rejection via immunosuppression. Standard conditioning regimens, typically comprising chemotherapy and/or radiotherapy, have proven successful in bone marrow clearance but are also associated with severe toxicities and high incidence of treatment-related mortality. Antibody-based conditioning is a developing field which, thus far, has largely shown an improved toxicity profile in experimental models and improved transplant outcomes, compared to traditional conditioning. Most antibody-based conditioning therapies involve monoclonal/naked antibodies, such as alemtuzumab for graft-versus-host disease prophylaxis and rituximab for Epstein-Barr virus prophylaxis, which are both in Phase II trials for inclusion in conditioning regimens. Nevertheless, alternative immune-based therapies, including antibody-drug conjugates, radio-labelled antibodies and CAR-T cells, are showing promise in a conditioning setting. Here, we analyse the current status of antibody-based drugs in pre-transplant conditioning regimens and assess their potential in the future of transplant biology.

Item Type: Article
Uncontrolled Keywords: Conditioning, Stem cell transplant, Graft-versus-host disease, Graft versus leukaemia, Antibody-drug conjugate, Monoclonal antibody, Immunotherapy
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User: Symplectic Admin
Date Deposited: 26 May 2022 08:27
Last Modified: 18 Jan 2023 21:01
DOI: 10.1186/s13045-022-01284-6
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