Proctor, Matthew S, Sutherland, George A, Canniffe, Daniel P 
ORCID: 0000-0002-5022-0437 and Hitchcock, Andrew
(2022)
The terminal enzymes of (bacterio)chlorophyll biosynthesis
ROYAL SOCIETY OPEN SCIENCE, 9 (5).
211903-.
ISSN 2054-5703, 2054-5703
|
Text
rsos.211903.pdf - Published version Download (1MB) | Preview |
Abstract
(Bacterio)chlorophylls are modified tetrapyrroles that are used by phototrophic organisms to harvest solar energy, powering the metabolic processes that sustain most of the life on Earth. Biosynthesis of these pigments involves enzymatic modification of the side chains and oxidation state of a porphyrin precursor, modifications that differ by species and alter the absorption properties of the pigments. (Bacterio)chlorophylls are coordinated by proteins that form macromolecular assemblies to absorb light and transfer excitation energy to a special pair of redox-active (bacterio)chlorophyll molecules in the photosynthetic reaction centre. Assembly of these pigment-protein complexes is aided by an isoprenoid moiety esterified to the (bacterio)chlorin macrocycle, which anchors and stabilizes the pigments within their protein scaffolds. The reduction of the isoprenoid 'tail' and its addition to the macrocycle are the final stages in (bacterio)chlorophyll biosynthesis and are catalysed by two enzymes, geranylgeranyl reductase and (bacterio)chlorophyll synthase. These enzymes work in conjunction with photosynthetic complex assembly factors and the membrane biogenesis machinery to synchronize delivery of the pigments to the proteins that coordinate them. In this review, we summarize current understanding of the catalytic mechanism, substrate recognition and regulation of these crucial enzymes and their involvement in thylakoid biogenesis and photosystem repair in oxygenic phototrophs.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | (bacterio)chlorophyll, chlorophyll synthase, ChlG, geranylgeranyl reductase, ChlP, photosynthesis |
| Divisions: | Faculty of Health & Life Sciences Faculty of Health & Life Sciences > Inst. Systems, Molec & Integrative Biology > Inst. Systems, Molec & Integrative Biology |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 26 May 2022 12:02 |
| Last Modified: | 16 Jun 2026 19:56 |
| DOI: | 10.1098/rsos.211903 |
| Related Websites: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3155532 |
| Disclaimer: | The University of Liverpool is not responsible for content contained on other websites from links within repository metadata. Please contact us if you notice anything that appears incorrect or inappropriate. |
Altmetric
Altmetric