Identification of genetic effects underlying type 2 diabetes in South Asian and European populations

Loh, Marie, Zhang, Weihua, Ng, Hong Kiat, Schmid, Katharina, Lamri, Amel, Tong, Lin, Ahmad, Meraj, Lee, Jung-Jin, Ng, Maggie CY, Petty, Lauren E
et al (show 37 more authors) (2022) Identification of genetic effects underlying type 2 diabetes in South Asian and European populations. COMMUNICATIONS BIOLOGY, 5 (1). 329-.

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South Asians are at high risk of developing type 2 diabetes (T2D). We carried out a genome-wide association meta-analysis with South Asian T2D cases (n = 16,677) and controls (n = 33,856), followed by combined analyses with Europeans (n<sub>eff</sub> = 231,420). We identify 21 novel genetic loci for significant association with T2D (P = 4.7 × 10<sup>-8</sup> to 5.2 × 10<sup>-12</sup>), to the best of our knowledge at the point of analysis. The loci are enriched for regulatory features, including DNA methylation and gene expression in relevant tissues, and highlight CHMP4B, PDHB, LRIG1 and other genes linked to adiposity and glucose metabolism. A polygenic risk score based on South Asian-derived summary statistics shows ~4-fold higher risk for T2D between the top and bottom quartile. Our results provide further insights into the genetic mechanisms underlying T2D, and highlight the opportunities for discovery from joint analysis of data from across ancestral populations.

Item Type: Article
Uncontrolled Keywords: Humans, Diabetes Mellitus, Type 2, Genetic Predisposition to Disease, Case-Control Studies, Polymorphism, Single Nucleotide, Genome-Wide Association Study, Asian People
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Population Health
Depositing User: Symplectic Admin
Date Deposited: 27 May 2022 07:51
Last Modified: 25 Jan 2023 13:12
DOI: 10.1038/s42003-022-03248-5
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