Nutritional prehabilitation in head and neck cancer: A systematic review

Cantwell, Linda A ORCID: 0000-0002-2585-5529, Fahy, Emer, Walters, Emily R and Patterson, Joanne M
(2022) Nutritional prehabilitation in head and neck cancer: A systematic review. [Preprint]

[thumbnail of Nutritional.prehab.pre-print.pdf] Text
Nutritional.prehab.pre-print.pdf - Author Accepted Manuscript

Download (694kB) | Preview


<jats:title>Abstract</jats:title> <jats:p><jats:bold>Purpose: </jats:bold>Prehabilitation affords an opportunity to support the management of malnutrition that is strongly associated with head and neck cancer. The purpose of this systematic review was to identify the components of nutritional prehabilitation interventions and their effects on nutritional and health outcomes in head and neck cancer patients.<jats:bold> </jats:bold><jats:bold>Methods: </jats:bold>A comprehensive search was completed within Medline (including PubMed), CINHAL, Cochrane database, EMBASE, PRoQUEST, clinical trials registries and grey literature to identify studies involving a nutritional intervention pre-treatment in head and neck cancer patients receiving any form of curative therapy. Nutritional intervention was defined as a specified period pre-treatment and outcomes measures had to include assessment of nutritional status or body composition. Quality of included studies was assessed using Cochrane risk of bias 2. <jats:bold>Results: </jats:bold>From 557 identified studies,<jats:bold> </jats:bold>two met the inclusion criteria. Due to the low number of studies a meta-analysis was not indicated. Both studies conducted a nutritional intervention using an “enriched formula” in malnourished patients prior to surgery. Neither study reported the intervention was effective for reducing weight loss, physical function, surgical complications, or length of stay versus the comparison<jats:bold>. </jats:bold><jats:bold>Conclusion: </jats:bold>There is limited nutritional prehabilitation research within head and neck cancer. An “enriched formula” provided in the prehabilitation period appears no more advantageous than routine standard nutritional formula in mitigating against the weight loss experienced in malnourished head and neck patient. Due to the malnutrition risks on diagnosis and the negative impact of poor nutritional status on clinical and functional outcomes robust nutritional prehabilitation research is required to inform clinical practice.</jats:p>

Item Type: Preprint
Uncontrolled Keywords: 32 Biomedical and Clinical Sciences, 4203 Health Services and Systems, 4205 Nursing, 42 Health Sciences, 3211 Oncology and Carcinogenesis, Nutrition, Patient Safety, Rare Diseases, Clinical Research, Dental/Oral and Craniofacial Disease, Prevention, Cancer, Oral and gastrointestinal, Cancer, 2 Zero Hunger
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Population Health
Faculty of Health and Life Sciences > Institute of Population Health > School of Health Sciences
Depositing User: Symplectic Admin
Date Deposited: 21 Jun 2022 08:22
Last Modified: 20 Jul 2024 10:13
DOI: 10.21203/
Related URLs: