Rola, Alda Cunha, Kalirai, Helen 
ORCID: 0000-0002-4440-2576, Taktak, Azzam FG, Eleuteri, Antonio ORCID: 0000-0003-0718-6672, Krishna, Yamini, Hussain, Rumana ORCID: 0000-0001-8208-5009, Heimann, Heinrich and Coupland, Sarah E ORCID: 0000-0002-1464-2069
(2022)
A Retrospective Analysis of 10 Years of Liver Surveillance Undertaken in Uveal Melanoma Patients Treated at the Supraregional "Liverpool Ocular Oncology Centre", UK.
CANCERS, 14 (9).
2187-.
|
Text
A Retrospective Analysis of 10 Years of Liver Surveillance Undertaken in Uveal Melanoma Patients Treated at the Supraregiona.pdf - Published version Download (2MB) | Preview |
Abstract
<h4>Purpose</h4>To determine liver screening frequency and modality in UM patients following primary treatment, and the characteristics of detected metastases.<h4>Methods</h4>A 10-year retrospective study of 615 UM patients undergoing liver surveillance in Liverpool. Information was collected from liver scan reports of these patients.<h4>Results</h4>Of 615 UM patients analyzed, there were 337 men (55%) and 278 women (45%). Median age at primary treatment was 61 years (range, 22-94). At study end, median follow-up was 5.1 years, with 375 patients (61%) alive and 240 deceased (39%). Of the deceased patients, 187 (78%) died due to metastatic UM; 24 (10%) deaths were due to other causes; and 29 (12%) patients died of unknown conditions. In total, 3854 liver scans were performed in the 615 UM patients, with a median of 6.2 scans per patient (range, 1-40). Liver MRI was most frequently performed (62.8%). In total, 229 (37%) UM patients developed metastases during the study period: 150 were detected via liver surveillance and 79 were observed post-mortem.<h4>Conclusions</h4>Metastatic UM onset is related to the size and genetic profiles of the primary UM, and can be predicted using the model LUMPO3. Regular liver surveillance allowed for timely detection of metastases, and through metastasectomy can lead to prolongation of life in some patients.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | liver surveillance, frequency, modality, detection of metastases, LUMPO3 model, new output of LUMPO3 |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology Faculty of Science and Engineering > School of Physical Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 22 Jul 2022 14:13 |
| Last Modified: | 18 Jan 2023 20:56 |
| DOI: | 10.3390/cancers14092187 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3159182 |
Dimensions
Dimensions
