Magnetization transfer imaging alterations and its diagnostic value in antipsychotic-naive first-episode schizophrenia



Lei, Du, Suo, Xueling, Qin, Kun, Pinaya, Walter HL, Ai, Yuan, Li, Wenbin, Kuang, Weihong, Lui, Su, Kemp, Graham J ORCID: 0000-0002-8324-9666, Sweeney, John A
et al (show 1 more authors) (2022) Magnetization transfer imaging alterations and its diagnostic value in antipsychotic-naive first-episode schizophrenia. TRANSLATIONAL PSYCHIATRY, 12 (1). 189-.

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Abstract

Magnetization transfer imaging (MTI) may provide more sensitivity and mechanistic understanding of neuropathological changes associated with schizophrenia than volumetric MRI. This study aims to identify brain magnetization transfer ratio (MTR) changes in antipsychotic-naïve first-episode schizophrenia (FES), and to correlate MTR findings with clinical symptom severity. A total of 143 individuals with antipsychotic-naïve FES and 147 healthy controls (HCs) were included and underwent 3.0 T brain MTI between August 2005 and July 2014. Voxelwise analysis was performed to test for MTR differences with family-wise error corrections. Relationships of these differences to symptom severity were assessed using partial correlations. Exploratory analyses using a support vector machine (SVM) classifier were conducted to discriminate FES from HCs using MTR maps. Model performance was examined using a 10-fold stratified cross-validation. Compared with HCs, individuals with FES exhibited higher MTR values in left thalamus, precuneus, cuneus, and paracentral lobule, that were positively correlated with schizophrenia symptom severity [precuneus (r = 0.34, P = 0.0004), cuneus (r = 0.33, P = 0.0006) and paracentral lobule (r = 0.37, P = 0.001)]. Whole-brain MTR maps identified individuals with FES with overall accuracy 75.5% (219 of 290 individuals) based on SVM approach. In antipsychotic-naïve FES, clinically relevant biophysical abnormalities detected by MTI mainly in the left parieto-occipital regions are informative about local brain pathology, and have potential as diagnostic markers.

Item Type: Article
Uncontrolled Keywords: Brain, Humans, Antipsychotic Agents, Magnetic Resonance Imaging, Brain Mapping, Schizophrenia
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences
Depositing User: Symplectic Admin
Date Deposited: 08 Aug 2022 07:19
Last Modified: 18 Jan 2023 20:53
DOI: 10.1038/s41398-022-01939-5
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3160625