Zhang, Feifei, Li, Fei, Yang, Hong, Jin, Yu, Lai, Wenli, Kemp, Graham J 
ORCID: 0000-0002-8324-9666, Jia, Zhiyun and Gong, Qiyong
(2022)
Altered Brain Topological Property Associated With Anxiety in Experimental Orthodontic Pain.
FRONTIERS IN NEUROSCIENCE, 16.
907216-.
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Altered Brain Topological Property Associated With Anxiety in Experimental Orthodontic Pain.pdf - Published version Download (1MB) | Preview |
Abstract
<h4>Background</h4>Orthodontic pain is orofacial pain caused by tooth movement. Anxiety is a strong predictor of the severity of such pain, but little is known about the underlying neuropsychological mechanisms of such effects. The purpose of this study was to investigate the effect of orthodontic pain on brain functional networks and to define the mediating role of anxiety in orthodontic pain and brain function.<h4>Methods</h4>Graph theory-based network analyses were applied to brain functional magnetic resonance imaging data from 48 healthy participants exposed to 24 h orthodontic pain stimuli and 49 healthy controls without any stimulation.<h4>Results</h4>In the experimental orthodontic pain stimulation, brain functional networks retained a small-world organization. At the regional level, the nodal centrality of ipsilateral brain nodes to the pain stimulus was enhanced; in contrast the nodal centrality of contralateral brain areas was decreased, especially the right mid-cingulate cortex, which is involved in pain intensity coding. Furthermore, anxiety mediated the relationship between nodal efficiency of mid-cingulate cortex and pain severity.<h4>Conclusion</h4>The results illuminate the neural mechanisms of orthodontic pain by revealing unbalanced hemispherical brain function related to the unilateral pain stimulation, and reveal clinically exploitable evidence that anxiety mediates the relationship between nodal function of right mid-cingulate cortex and orthodontic pain.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | orthodontic pain, rs-fMRI, graph theory, functional connectivity, anxiety |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 08 Aug 2022 07:18 |
| Last Modified: | 18 Jan 2023 20:53 |
| DOI: | 10.3389/fnins.2022.907216 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3160626 |
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