Arterial stiffness and atrial fibrillation: shared mechanisms, clinical implications and therapeutic options.


Vio, Riccardo, Giordani, Andrea S, Stefil, Maria, Madine, Jillian ORCID: 0000-0001-9963-5871, Fairbairn, Timothy, Themistoclakis, Sakis, Salvi, Paolo, Caforio, Alida LP, Shantsila, Alena ORCID: 0000-0002-0594-8576, Shantsila, Eduard ORCID: 0000-0002-2429-6980 et al (show 4 more authors) (2022) Arterial stiffness and atrial fibrillation: shared mechanisms, clinical implications and therapeutic options. Journal of hypertension, 40 (9). pp. 1639-1646.

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Abstract

Arterial stiffness (AS) and atrial fibrillation (AF) share commonalities in molecular and pathophysiological mechanisms and numerous studies have analyzed their reciprocal influence. The gold standard for AS diagnosis is represented by aortic pulse wave velocity, whose measurement can be affected by arrhythmias characterized by irregularities in heart rhythm, such as AF. Growing evidence show that patients with AS are at high risk of AF development. Moreover, the subset of AF patients with AS seems to be more symptomatic and rhythm control strategies are less effective in this population. Reducing AS through de-stiffening interventions may be beneficial for patients with AF and can be a new appealing target for the holistic approach of AF management. In this review, we discuss the association between AS and AF, with particular interest in shared mechanisms, clinical implications and therapeutic options.

Item Type: Article
Uncontrolled Keywords: arterial stiffness, atrial fibrillation, cardiovascular prevention, cardiovascular remodeling, cardiovascular risk
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences
Faculty of Health and Life Sciences > Institute of Population Health
Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User: Symplectic Admin
Date Deposited: 22 Aug 2022 08:00
Last Modified: 22 Jul 2023 01:30
DOI: 10.1097/hjh.0000000000003223
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3161650
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