Ecological lipidology

Trautenberg, Laura Christin, Brankatschk, Marko, Shevchenko, Andrej, Wigby, Stuart ORCID: 0000-0002-2260-2948 and Reinhardt, Klaus (2022) Ecological lipidology ELIFE, 11. e79288-. ISSN 2050-084X, 2050-084X

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Abstract

Dietary lipids (DLs), particularly sterols and fatty acids, are precursors for endogenous lipids that, unusually for macronutrients, shape cellular and organismal function long after inges-tion. These functions – cell membrane structure, intracellular signalling, and hormonal activity – vary with the identity of DLs, and scale up to influence health, survival, and reproductive fitness, thereby affecting evolutionary change. Our Ecological Lipidology approach integrates biochemical mechanisms and molecular cell biology into evolution and nutritional ecology. It exposes our need to understand environmental impacts on lipidomes, the lipid specificity of cell functions, and predicts the evolution of lipid-based diet choices. Broad interdisciplinary implications of Ecological Lipidology include food web alterations, species responses to environmental change, as well as sex differences and lifestyle impacts on human nutrition, and opportunities for DL-based therapies.

Item Type:	Article
Uncontrolled Keywords:	diet choice, fatty acids, fitness, food web, membrane, sterols
Divisions:	Faculty of Health & Life Sciences Faculty of Health & Life Sciences > Inst. Infection, Vet & Ecological Sciences
Depositing User:	Symplectic Admin
Date Deposited:	27 Sep 2022 10:04
Last Modified:	16 Jun 2026 11:07
DOI:	10.7554/eLife.79288
Related Websites:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3164976
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