Prevalence of amyloid blood clots in COVID-19 plasma

Pretorius, Etheresia ORCID: 0000-0002-9108-2384, Venter, Chantelle, Laubscher, Gert Jacobus, Lourens, Petrus Johannes, Steenkamp, Janami and Kell, Douglas ORCID: 0000-0001-5838-7963
(2020) Prevalence of amyloid blood clots in COVID-19 plasma. 2020.07.28.20163543-.

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The rapid detection of COVID-19 uses genotypic testing for the presence of SARS-Cov-2 virus in nasopharyngeal swabs, but it can have a poor sensitivity. A rapid, host-based physiological test that indicated whether the individual was infected or not would be highly desirable. Coagulaopathies are a common accompaniment to COVID-19, especially micro-clots within the lungs. We show here that microclots can be detected in the native plasma of COVID-19 patient, and in particular that such clots are amyloid in nature as judged by a standard fluorogenic stain. This provides a rapid and convenient test (P<0.0001), and suggests that the early detection and prevention of such clotting could have an important role in therapy.

Item Type: Article
Uncontrolled Keywords: Prevention, Lung, Brain Disorders, Neurosciences, Neurodegenerative, Infectious Diseases, 3 Good Health and Well Being
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User: Symplectic Admin
Date Deposited: 12 Oct 2022 08:18
Last Modified: 15 Mar 2024 15:01
DOI: 10.1101/2020.07.28.20163543
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