Dynamic contrast-enhanced MRI and Doppler sonography in patients with squamous cell carcinoma of head and neck treated with induction chemotherapy

Chawla, Sanjeev, Loevner, Laurie, Mohan, Suyash, Lin, Alexander, Sehgal, Chandra M and Poptani, Harish ORCID: 0000-0002-0593-3235 (2022) Dynamic contrast-enhanced MRI and Doppler sonography in patients with squamous cell carcinoma of head and neck treated with induction chemotherapy JOURNAL OF CLINICAL ULTRASOUND, 50 (9). pp. 1353-1359. ISSN 0091-2751, 1097-0096

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Abstract

In view of the inherent limitations associated with performing dynamic contrast enhanced-magnetic resonance imaging (DCE-MRI) in clinical settings, current study was designed to provide a proof of principle that Doppler sonography and DCE-MRI derived perfusion parameters yield similar hemodynamic information from metastatic lymph nodes in squamous cell carcinomas of head and neck (HNSCCs). Strong positive correlations between volume fraction of plasma space in tissues (V<inf>p</inf>) and blood volume (r = 0.72, p = 0.02) and between V<inf>p</inf> and %area perfused (r = 0.65, p = 0.04) were observed. Additionally, a moderate positive correlation trending towards significance was obtained between volume transfer constant (K^trans) and %area perfused (r = 0.49, p = 0.09).

Item Type:	Article
Uncontrolled Keywords:	Doppler sonography, dynamic contrast enhanced-MRI, head and neck squamous cell carcinoma, induction chemotherapy, perfusion parameters
Divisions:	Faculty of Health & Life Sciences Faculty of Health & Life Sciences > Inst. Systems, Molec & Integrative Biology > Inst. Systems, Molec & Integrative Biology
Depositing User:	Symplectic Admin
Date Deposited:	17 Oct 2022 08:25
Last Modified:	24 Jan 2026 03:54
DOI:	10.1002/jcu.23361
Related Websites:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3165484
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