The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms

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Alaggio, R ORCID: 0000-0003-3915-3816, Amador, C ORCID: 0000-0003-0352-5526, Anagnostopoulos, I ORCID: 0000-0002-5043-6043, Attygalle, AD ORCID: 0000-0001-5034-8150, Araujo, IBDO, Berti, E ORCID: 0000-0001-6753-4910, Bhagat, G ORCID: 0000-0001-6250-048X, Borges, AM, Boyer, D ORCID: 0000-0001-9948-3193, Calaminici, M ORCID: 0000-0003-4094-1633 et al (show 73 more authors) , Chadburn, A ORCID: 0000-0002-9499-8638, Chan, JKC ORCID: 0000-0001-5068-6707, Cheuk, W ORCID: 0000-0003-3160-9591, Chng, WJ ORCID: 0000-0003-2578-8335, Choi, JK ORCID: 0000-0002-2861-0180, Chuang, SS ORCID: 0000-0003-3971-525X, Coupland, SE ORCID: 0000-0002-1464-2069, Czader, M ORCID: 0000-0002-6173-6500, Dave, SS ORCID: 0000-0003-4848-9768, de Jong, D ORCID: 0000-0002-9725-4060, Du, MQ ORCID: 0000-0002-1017-5045, Elenitoba-Johnson, KS ORCID: 0000-0002-1082-1545, Ferry, J ORCID: 0000-0002-3428-4166, Geyer, J ORCID: 0000-0002-4424-6139, Gratzinger, D ORCID: 0000-0002-9182-8123, Guitart, J ORCID: 0000-0001-7635-9237, Gujral, S ORCID: 0000-0001-8648-1172, Harris, M ORCID: 0000-0002-9956-664X, Harrison, CJ ORCID: 0000-0002-0526-6794, Hartmann, S ORCID: 0000-0003-3424-1091, Hochhaus, A ORCID: 0000-0003-0626-0834, Jansen, PM ORCID: 0000-0002-2361-9303, Karube, K, Kempf, W ORCID: 0000-0002-6552-8629, Khoury, J ORCID: 0000-0003-2621-3584, Kimura, H ORCID: 0000-0001-8063-5660, Klapper, W ORCID: 0000-0001-7208-4117, Kovach, AE ORCID: 0000-0002-6742-6749, Kumar, S ORCID: 0000-0001-5392-9284, Lazar, AJ ORCID: 0000-0002-6395-4499, Lazzi, S ORCID: 0000-0002-2218-3771, Leoncini, L ORCID: 0000-0002-7457-300X, Leung, N ORCID: 0000-0002-5651-1411, Leventaki, V ORCID: 0000-0003-1145-3550, Li, XQ ORCID: 0000-0002-8758-2191, Lim, MS ORCID: 0000-0002-0415-2867, Liu, WP ORCID: 0000-0002-6819-5612, Louissaint, A ORCID: 0000-0001-6707-917X, Marcogliese, A ORCID: 0000-0002-1458-9675, Medeiros, LJ ORCID: 0000-0001-6577-8006, Michal, M ORCID: 0000-0003-4403-7027, Miranda, RN ORCID: 0000-0002-8467-5464, Mitteldorf, C ORCID: 0000-0002-0971-0370, Montes-Moreno, S ORCID: 0000-0002-3565-8262, Morice, W ORCID: 0000-0002-5801-2501, Nardi, V ORCID: 0000-0002-0486-416X, Naresh, KN ORCID: 0000-0003-3807-3638, Natkunam, Y ORCID: 0000-0002-9816-1018, Ng, SB ORCID: 0000-0001-6051-6410, Oschlies, I ORCID: 0000-0002-4003-6855, Ott, G ORCID: 0000-0001-7990-6793, Parrens, M ORCID: 0000-0002-4335-4138, Pulitzer, M ORCID: 0000-0002-0606-9186, Rajkumar, SV ORCID: 0000-0002-5862-1833, Rawstron, AC ORCID: 0000-0003-0798-9790, Rech, K ORCID: 0000-0001-6770-2339, Rosenwald, A ORCID: 0000-0001-7282-8374, Said, J ORCID: 0000-0001-9474-2563, Sarkozy, C ORCID: 0000-0002-1942-9304, Sayed, S ORCID: 0000-0002-3472-511X, Saygin, C ORCID: 0000-0001-7617-8356, Schuh, A ORCID: 0000-0002-3938-8490, Sewell, W ORCID: 0000-0002-3586-8761, Siebert, R ORCID: 0000-0002-6492-5323, Sohani, AR ORCID: 0000-0002-6307-4854, Tooze, R ORCID: 0000-0003-2915-7119, Traverse-Glehen, A ORCID: 0000-0002-3934-0120, Vega, F ORCID: 0000-0001-5956-452X, Vergier, B ORCID: 0000-0002-3498-3143, Wechalekar, AD ORCID: 0000-0002-4406-7237, Wood, B, Xerri, L ORCID: 0000-0002-8672-9921 and Xiao, W ORCID: 0000-0001-8586-8500 (2022) The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms Leukemia, 36 (7). pp. 1720-1748. ISSN 0887-6924, 1476-5551

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Abstract

We herein present an overview of the upcoming 5^th edition of the World Health Organization Classification of Haematolymphoid Tumours focussing on lymphoid neoplasms. Myeloid and histiocytic neoplasms will be presented in a separate accompanying article. Besides listing the entities of the classification, we highlight and explain changes from the revised 4^th edition. These include reorganization of entities by a hierarchical system as is adopted throughout the 5^th edition of the WHO classification of tumours of all organ systems, modification of nomenclature for some entities, revision of diagnostic criteria or subtypes, deletion of certain entities, and introduction of new entities, as well as inclusion of tumour-like lesions, mesenchymal lesions specific to lymph node and spleen, and germline predisposition syndromes associated with the lymphoid neoplasms.

Item Type:	Article
Uncontrolled Keywords:	Humans, Lymphoma, Hematologic Neoplasms, World Health Organization
Divisions:	Faculty of Health & Life Sciences Faculty of Health & Life Sciences > Inst. Systems, Molec & Integrative Biology > Inst. Systems, Molec & Integrative Biology
Depositing User:	Symplectic Admin
Date Deposited:	18 Oct 2022 15:04
Last Modified:	01 Mar 2026 02:03
DOI:	10.1038/s41375-022-01620-2
Open Access URL:	https://www.nature.com/articles/s41375-022-01620-2
Related Websites:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3165621
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