SARS-CoV-2 in dialysis patients and the impact of vaccination

Moore, Louise Rachel, Al-Jaddou, Noor, Wodeyar, Harsha, Sharma, Asheesh, Schulz, Michael ORCID: 0000-0001-6500-2697, Rao, Anirudh ORCID: 0000-0002-3202-2832 and Abraham, Kottarathil (2022) SARS-CoV-2 in dialysis patients and the impact of vaccination. BMC NEPHROLOGY, 23 (1). 317-.

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Official URL: http://dx.doi.org/10.1186/s12882-022-02940-2

Abstract

<h4>Background</h4>In centre haemodialysis (ICHD) patients have been identified as high risk of contracting Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection due to frequent healthcare contact and poor innate and adaptive immunity. Our ICHD patients were offered immunisation from January 2021. We aimed to assess outcomes following SARS-CoV-2 infection and report on the effect of vaccination in our ICHD patients.<h4>Methods</h4>Demographics, SARS-CoV-2 status, hospitalisation, mortality and vaccination status were analysed. From 11<sup>th</sup> March 2020 to 31<sup>st</sup> March 2021, 662 ICHD patients were included in the study and these patients were then followed up until 31<sup>st</sup> August 2021.<h4>Results</h4>SARS-CoV-2 infection occurred in 28.4% with 51.1% of them requiring hospitalisation in contrast to community infection rates of 13.9% and hospitalisation of 9.0%. 28-day mortality was 19.2% in comparison to 1.9% of the community. Mortality increased to 34.0% over the study period. Mortality over the study period was 1.8 times in infected patients (HR 1.81 (1.32-2.49) P < 0.001) despite adjustment for age, gender and ethnicity. 91.3% of ICHD patients have now received both doses of SARS-CoV-2 vaccinations.<h4>Conclusions</h4>ICHD patients are at increased risk of acquiring SARS-CoV-2, with increased rates of hospitalisation and mortality. The increased mortality extends well beyond the 28 days post-infection and persists in those who have recovered. Peaks and troughs in infection rates mirrored community trends. Preliminary data indicates that the SARS-CoV-2 vaccination provides protection to ICHD patients, with ICHD case rates now comparable to that of the local population.

Item Type:	Article
Uncontrolled Keywords:	Dialysis patients, Efficacy, SARS-CoV-2, Vaccination
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences > School of Medicine
Depositing User:	Symplectic Admin
Date Deposited:	20 Oct 2022 08:28
Last Modified:	18 Jan 2023 19:49
DOI:	10.1186/s12882-022-02940-2
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3165658