Uncovering protein function: from classification to complexes

Morris, Rhiannon, Black, Katrina A and Stollar, Elliott J ORCID: 0000-0001-9895-0335 (2022) Uncovering protein function: from classification to complexes. ESSAYS IN BIOCHEMISTRY, 66 (3). pp. 255-285.

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Official URL: http://dx.doi.org/10.1042/ebc20200108

Abstract

Almost all interactions and reactions that occur in living organisms involve proteins. The various biological roles of proteins include, but are not limited to, signal transduction, gene transcription, cell death, immune function, structural support, and catalysis of all the chemical reactions that enable organisms to survive. The varied roles of proteins have led to them being dubbed 'the workhorses of all living organisms'. This article discusses the functions of proteins and how protein function is studied in a laboratory setting. In this article, we begin by examining the functions of protein domains, followed by a discussion of some of the major classes of proteins based on their function. We consider protein binding in detail, which is central to protein function. We then examine how protein function can be altered through various mechanisms including post-translational modification, and changes to environment, oligomerisation and mutations. Finally, we consider a handful of the techniques employed in the laboratory to understand and measure the function of proteins.

Item Type:	Article
Uncontrolled Keywords:	Proteins, Signal Transduction, Protein Processing, Post-Translational, Protein Binding
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology > School of Life Sciences
Depositing User:	Symplectic Admin
Date Deposited:	28 Oct 2022 15:28
Last Modified:	18 Jan 2023 19:48
DOI:	10.1042/EBC20200108
Open Access URL:	https://doi.org/10.1042/EBC20200108
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3165869