Investigation of the relationship between contact lens design parameters and refractive changes in Ortho-K

Wu, Lo-Yu, Esporcatte, Louise Pellegrino Gomes, Li, Wen-Kai, Lin, Wen-Pin, Wu, Richard, White, Lynn, Saloma, Marcella Q, Lopes, Bernardo T, Ambrosio, Renato and Abass, Ahmed ORCID: 0000-0002-8622-4632
(2022) Investigation of the relationship between contact lens design parameters and refractive changes in Ortho-K. HELIYON, 8 (11). e11699-.

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<h4>Purpose</h4>To investigate the relationship between Ortho-K contact lens design parameters and refractive power change of the eye through a parametric mathematical representation.<h4>Methods</h4>The current study utilises fully anonymized records of 249 eyes, 132 right eyes, and 117 left eyes from subjects aged 14.1 ± 4.0 years on average (range 9-38 years) which were selected for secondary analysis processing. The data were split into 3 groups (G1 up to 35 days wear, from 10 to 35 days, G2 up to 99 days wear, more than 35-99 days & G3 more than 100 days wear) according to the length of time, in days, that the lenses were worn. Corneal shape was measured before and after contact lens wear using the Medmont E300 topographer, from which height and distance files were read by a custom-built MATLAB code to construct the corneal anterior surface independently. Changes in refractive power pre and post-Ortho-K wear were determined using constructed tangential refractive power maps from which both centrally flattened and annular steepened zones were automatically bounded, hence used to determine the refractive power change.<h4>Results</h4>On average, flat Sim-K and steep Sim-K were reduced after Ortho-K lens wear by 1.6 ± 1.3 D and 1.3 ± 1.4 D respectively. The radius of the base curve was correlated with the mean central flattened zone power change strongly in G1 (R = 0.7, p < 0.001) and moderately in G2 (R = 0.4) and G3 (R = 0.4, p < 0.001). Hence, a strong correlation with the base curve was recorded in group G1 and moderate in G2 and G3. The reverse curve was very strongly correlated to the mean central flattened zone power change in G1 (R = 0.8, p < 0.001) and strongly correlated with G2 (R = 0.6, p < 0.001) and G3 (R = 0.7, p < 0.001). The reverse curve was also strongly correlated with the mean annular steepened zone power change among all groups G1, G2, and G3 (R = 0.7, R = 0.6 and R = 0.6) respectively (p < 0.001).<h4>Conclusions</h4>Although the central corneal refractive power change was strongly correlated to the Ortho-K lens base curve, it characterized only 50% of the target power change. However, the annular steepened zone refractive power change appears to be a clearer predictor of target power change, as there appears to be a one-to-one inverse relationship with the target refractive power correction. Differences between these results and the literature may be a result of the topography software smoothing effect.

Item Type: Article
Uncontrolled Keywords: Eye, Cornea, Ortho-K, Contact lenses, Target power change
Depositing User: Symplectic Admin
Date Deposited: 14 Nov 2022 09:53
Last Modified: 17 May 2023 22:16
DOI: 10.1016/j.heliyon.2022.e11699
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