Expression of cannabinoid receptors CB1 and CB2 in canine cutaneous mast cell tumours

Rinaldi, Valentina, Boari, Andrea, Ressel, Lorenzo ORCID: 0000-0002-6614-1223, Bongiovanni, Laura, Crisi, Paolo Emidio, Cabibbo, Emanuele and Finotello, Riccardo
(2022) Expression of cannabinoid receptors CB1 and CB2 in canine cutaneous mast cell tumours. RESEARCH IN VETERINARY SCIENCE, 152. pp. 530-536.

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Cannabinoid receptors (CB1 and CB2) belong to endocannabinoid system (ECS), which is also composed from endocannabinoids and the enzymatic systems involved in their biosynthesis and degradation. The expression of CB1 and CB2 have been previously identified in normal canine mast cell and in atopic dermatitis. Canine cutaneous mast cell tumours (cMCTs) are among the most common cutaneous neoplasms in dogs and have a highly variable clinical behaviour. Expression of CB1-CB2 was assessed by means of immunohistochemistry in thirty-seven dogs (from 2019 to 2021) with proven histological diagnosis of cMCT. Dogs were divided in two groups according to the Kiupel's grading system: high-grade (HG) cMCT and low-grade (LG) cMCT. A semiquantitative (score 0-3) and quantitative assessment of immunoreactivity (IR) was performed for each case. Our results show that there CB1 and CB2 are highly expressed in LG- cMCT, in contrast to HG- cMCT.

Item Type: Article
Uncontrolled Keywords: Cannabinoid, Dog, Histopathology, Immunohistochemistry, Mast cell tumor
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences
Depositing User: Symplectic Admin
Date Deposited: 16 Nov 2022 11:44
Last Modified: 18 Sep 2023 01:30
DOI: 10.1016/j.rvsc.2022.09.013
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