Quality of life outcomes in incidental and operated meningiomas (QUALMS): a cross-sectional cohort study

Keshwara, Sumirat MM, Gillespie, Conor SS, Mustafa, Mohammad AA, George, Alan MM, Richardson, George EE, Clynch, Abigail LL, Wang, Justin ZZ, Lawson, David DA, Gilkes, Catherine EE, Farah, J Osman
et al (show 8 more authors) (2022) Quality of life outcomes in incidental and operated meningiomas (QUALMS): a cross-sectional cohort study. JOURNAL OF NEURO-ONCOLOGY, 161 (2). pp. 317-327.

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<h4>Introduction</h4>Few studies have evaluated meningioma patients' longer-term health-related quality of life (HRQoL) following diagnosis and treatment, particularly in those with incidental, actively monitored tumours.<h4>Methods</h4>A single-center, cross-sectional study was completed. Adult patients with surgically managed or actively monitored meningioma with more than five years of follow-up were included. The patient-reported outcome measures RAND SF-36, EORTC QLQ-C30 and QLQ-BN20 were used to evaluate HRQoL. HRQoL scores were compared to normative population data. Outcome determinants were evaluated using multivariate linear regression analysis.<h4>Results</h4>243 patient responses were analyzed, and the mean time from diagnosis was 9.8 years (range 5.0-40.3 years). Clinically relevant, statistically significant HRQoL impairments were identified across several SF-36 and QLQ-C30 domains. Increasing education level (β = 2.9, 95% CI 0.9 to 4.9), P = .004), employment (β = 7.7, 95% CI 2.2 to 13.1, P = .006) and absence of postoperative complications (β=-6.7, 95% CI -13.2 to (-)0.3, P = .041) were associated with a better QLQ-C30 summary score. Other tumour and treatment variables were not.<h4>Conclusion</h4>This study highlights the longer-term disease burden of patients with meningioma nearly one decade after diagnosis or surgery. Patients with actively monitored meningioma have similar HRQoL to operated meningioma patients. Healthcare professionals should be mindful of HRQoL impairments and direct patients to sources of support as needed.

Item Type: Article
Uncontrolled Keywords: Meningioma, Active monitoring, Surgery, Quality of life
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User: Symplectic Admin
Date Deposited: 22 Dec 2022 08:01
Last Modified: 14 Mar 2023 13:32
DOI: 10.1007/s11060-022-04198-y
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3166752