Introduction and Clinical Validation of an Updated Biomechanically Corrected Intraocular Pressure bIOP (v2)

Eliasy, Ashkan ORCID: 0000-0002-4473-1900, Lopes, Bernardo T, Wang, Junjie, Abass, Ahmed ORCID: 0000-0002-8622-4632, Vinciguerra, Riccardo, Vinciguerra, Paolo, Bao, Fang-jun and Elsheikh, Ahmed ORCID: 0000-0001-7456-1749
(2022) Introduction and Clinical Validation of an Updated Biomechanically Corrected Intraocular Pressure bIOP (v2). CURRENT EYE RESEARCH, 48 (4). pp. 382-391.

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<h4>Purpose</h4>To improve the stability of the Corvis ST biomechanically-corrected intraocular pressure measurements (bIOP) after refractive surgery and its independence of corneal biomechanics.<h4>Methods</h4>A parametric study was carried out using numerical models simulating the behavior of the eye globe under the effects of IOP and Corvis ST external air pressure and used to develop a new algorithm for bIOP; bIOP(v2). It was tested on 528 healthy participants to evaluate correlations with CCT and age. Its ability to compensate for the geometrical changes was tested in 60 LASIK and 80 SMILE patients with six months follow up. The uncorrected Corvis ST IOP (CVS-IOP) and the two versions of biomechanically corrected IOP; bIOP(v1) and bIOP(v2), were compared.<h4>Results</h4>In the healthy dataset, bIOP(v2) had weak and non-significant correlation with both CCT (R = -0.048, <i>p</i> = .266) and age (R = 0.085, <i>p</i> = .052). For bIOP(v1), the correlation was non-significant with CCT (R = -0.064, <i>p</i> = .139) but significant with age (R = -0.124, <i>p</i> < .05). In both LASIK and SMILE groups, the median change in bIOP(v2) following surgery was below 1 mmHg at follow-up stages and the interquartile range was smaller than both bIOP(v1) and CVS-IOP.<h4>Conclusion</h4>The bIOP(v2) algorithm performs better than bIOP(v1) and CVS-IOP in terms of correlation with CCT and age. The bIOP(v2) also demonstrated the smallest variation after LASIK and SMILE refractive surgeries indicating improved ability to compensate for geometrical changes.

Item Type: Article
Uncontrolled Keywords: Intraocular pressure, keratoconus, cornea, biomechanics
Divisions: Faculty of Science and Engineering > School of Engineering
Depositing User: Symplectic Admin
Date Deposited: 03 Jan 2023 14:12
Last Modified: 11 Apr 2023 10:56
DOI: 10.1080/02713683.2022.2162087
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