Galectin-2 in Health and Diseases

Negedu, MN ORCID: 0000-0003-3701-162X, Duckworth, CA ORCID: 0000-0001-7971-3561 and Yu, LG ORCID: 0000-0001-9641-3712 (2023) Galectin-2 in Health and Diseases International Journal of Molecular Sciences, 24 (1). 341-. ISSN 1661-6596, 1422-0067

Access the full-text of this item by clicking on the Open Access link.

Abstract

Galectin-2 is a prototype member of the galactoside-binding galectin family. It is predominately expressed in the gastrointestinal tract but is also detected in several other tissues such as the placenta and in the cardiovascular system. Galectin-2 expression and secretion by epithelial cells has been reported to contribute to the strength of the mucus layer, protect the integrity of epithelia. A number of studies have also suggested the involvement of galectin-2 in tissue inflammation, immune response and cell apoptosis. Alteration of galectin-2 expression occurs in inflammatory bowel disease, coronary artery diseases, rheumatoid arthritis, cancer, and pregnancy disorders and has been shown to be involved in disease pathogenesis. This review discusses our current understanding of the role and actions of galectin-2 in regulation of these pathophysiological conditions.

Item Type:	Article
Uncontrolled Keywords:	galectin-2, gastrointestinal tract, apoptosis, immune cell, pregnancy disorders
Divisions:	Faculty of Health & Life Sciences Faculty of Health & Life Sciences > Inst. Systems, Molec & Integrative Biology > Inst. Systems, Molec & Integrative Biology
Depositing User:	Symplectic Admin
Date Deposited:	03 Jan 2023 11:46
Last Modified:	24 Jan 2026 04:01
DOI:	10.3390/ijms24010341
Open Access URL:	https://doi.org/10.3390/ijms24010341
Related Websites:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3166820
Disclaimer:	The University of Liverpool is not responsible for content contained on other websites from links within repository metadata. Please contact us if you notice anything that appears incorrect or inappropriate.