Galectin-2 in Health and Diseases

Negedu, Muhammed N, Duckworth, Carrie A and Yu, Lu-Gang ORCID: 0000-0001-9641-3712
(2023) Galectin-2 in Health and Diseases. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24 (1). 341-.

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Galectin-2 is a prototype member of the galactoside-binding galectin family. It is predominately expressed in the gastrointestinal tract but is also detected in several other tissues such as the placenta and in the cardiovascular system. Galectin-2 expression and secretion by epithelial cells has been reported to contribute to the strength of the mucus layer, protect the integrity of epithelia. A number of studies have also suggested the involvement of galectin-2 in tissue inflammation, immune response and cell apoptosis. Alteration of galectin-2 expression occurs in inflammatory bowel disease, coronary artery diseases, rheumatoid arthritis, cancer, and pregnancy disorders and has been shown to be involved in disease pathogenesis. This review discusses our current understanding of the role and actions of galectin-2 in regulation of these pathophysiological conditions.

Item Type: Article
Uncontrolled Keywords: galectin-2, gastrointestinal tract, apoptosis, immune cell, pregnancy disorders
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User: Symplectic Admin
Date Deposited: 03 Jan 2023 11:46
Last Modified: 25 Jan 2023 07:29
DOI: 10.3390/ijms24010341
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