Veselka, Josef, Faber, Lothar, Liebregts, Max, Cooper, Robert, Januska, Jaroslav, Kashtanov, Maksim, Dabrowski, Maciej, Hansen, Peter Riis, Seggewiss, Hubert, Bonaventura, Jiri et al (show 7 more authors)
(2021)
Alcohol dose in septal ablation for hypertrophic obstructive cardiomyopathy.
INTERNATIONAL JOURNAL OF CARDIOLOGY, 333.
pp. 127-132.
ISSN 0167-5273, 1874-1754
Abstract
<h4>Background</h4>The aim of this study was to evaluate short- and long-term outcomes related to dose of alcohol administered during alcohol septal ablation (ASA) in patients with hypertrophic obstructive cardiomyopathy (HOCM). Current guidelines recommend using 1-3 mL of alcohol administered in the target septal perforator artery, but this recommendation is based more on practical experience of interventionalists rather than on systematic evidence.<h4>Methods</h4>We included 1448 patients and used propensity score to match patients who received a low-dose (1.0-1.9 mL) versus a high-dose (2.0-3.8 mL) of alcohol during ASA.<h4>Results</h4>The matched cohort analysis comprised 770 patients (n = 385 in both groups). There was a similar occurrence of 30-day post-procedural adverse events (13% vs. 12%; p = 0.59), and similar all-cause mortality rates (0.8% vs. 0.5%; p = 1) in the low-dose group and the high-dose group, respectively. In the long-term follow-up (5.4 ± 4.5 years), a total of 110 (14%) patients died representing 2.58 deaths and 2.64 deaths per 100 patient-years in the low dose and the high dose group (logrank, p = 0.92), respectively. There were no significant differences in the long-term dyspnea and left ventricular outflow gradient between the two groups. Patients treated with a low-dose of alcohol underwent more subsequent septal reduction procedures (logrank, p = 0.04).<h4>Conclusions</h4>Matched HOCM patients undergoing ASA with a low-dose (1.0-1.9 mL) or a high-dose (2.0-3.8 mL) of alcohol had similar short- and long-term outcomes. A higher rate of repeated septal reduction procedures was observed in the group treated with a low-dose of alcohol.
Item Type: | Article |
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Uncontrolled Keywords: | Alcohol dose, Alcohol septal ablation, Hypertrophic cardiomyopathy |
Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences |
Depositing User: | Symplectic Admin |
Date Deposited: | 18 Jan 2023 10:19 |
Last Modified: | 07 Dec 2024 21:03 |
DOI: | 10.1016/j.ijcard.2021.02.056 |
Open Access URL: | https://doi.org/10.1016/j.ijcard.2021.02.056 |
Related URLs: | |
URI: | https://livrepository.liverpool.ac.uk/id/eprint/3167114 |