Assessment of Corneal Angiography Filling Patterns in Corneal Neovascularization

Pagano, Luca, Shah, Haider, Gadhvi, Kunal, Ahmad, Mohammad ORCID: 0000-0002-5972-0358, Menassa, Nardine ORCID: 0000-0003-2512-4889, Coco, Giulia, Kaye, Stephen ORCID: 0000-0003-0390-0592 and Romano, Vito ORCID: 0000-0002-5148-7643
(2023) Assessment of Corneal Angiography Filling Patterns in Corneal Neovascularization. JOURNAL OF CLINICAL MEDICINE, 12 (2). 633-.

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The purpose of the paper is to describe vascular filling patterns in corneal neovascularization (CoNV) and evaluate the effect of corneal lesion location, CoNV surface area and multi-quadrant CoNV involvement on the filling pattern. It is a retrospective study of patients who were investigated for CoNV using fluorescein angiography (FA) or indocyanine green angiography (ICGA) between January 2010 and July 2020. Angiography images were graded and analyzed multiple independent corneal specialists. The corneal surface was divided into four quadrants and patient information was obtained through electronic records. A total of 133 eyes were analyzed. Corneal lesions were located on the peripheral (72%) or central (28%) cornea. Central lesions were associated with multi-quadrant CoNV more frequently than peripheral lesions (<i>p</i> = 0.15). CoNV located within the same quadrant of the corneal lesion was often first to fill (88.4%). In multi-quadrant CoNV, the physiological inferior-superior-nasal-temporal order of filling was usually respected (61.7%). Central lesions resulted in larger CoNV surface area than peripheral lesions (<i>p</i> = 0.09). In multi-quadrant CoNV, the largest area of neovascularization was also the first to fill in (peripheral lesion 74%, central lesion 65%). Fillings patterns in healthy corneas have previously been reported. Despite CoNV development, these patterns are usually respected. Several factors that may influence filling patterns have been identified, including corneal lesion location, CoNV surface area and aetiology of CoNV. Understanding filling patterns of neovascularization allows for the identification of areas at higher risk of developing CoNV, aiding in earlier detection and intervention of CoNV.

Item Type: Article
Uncontrolled Keywords: corneal neovascularization, corneal vessels, CoNV, vessels filling pattern, ISNT rule
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences
Faculty of Health and Life Sciences > Clinical Directorate
Depositing User: Symplectic Admin
Date Deposited: 31 Jan 2023 10:39
Last Modified: 07 Feb 2023 18:22
DOI: 10.3390/jcm12020633
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