Circulating monocytes in acute pancreatitis

Liu, Shiyu, Szatmary, Peter, Lin, Jing-wen, Wang, Qiqi, Sutton, Robert ORCID: 0000-0001-6600-562X, Chen, Lu, Liu, Tingting, Huang, Wei and Xia, Qing
(2022) Circulating monocytes in acute pancreatitis. FRONTIERS IN IMMUNOLOGY, 13. 1062849-.

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Acute pancreatitis is a common gastrointestinal disease characterized by inflammation of the exocrine pancreas and manifesting itself through acute onset of abdominal pain. It is frequently associated with organ failure, pancreatic necrosis, and death. Mounting evidence describes monocytes - phagocytic, antigen presenting, and regulatory cells of the innate immune system - as key contributors and regulators of the inflammatory response and subsequent organ failure in acute pancreatitis. This review highlights the recent advances of dynamic change of numbers, phenotypes, and functions of circulating monocytes as well as their underling regulatory mechanisms with a special focus on the role of lipid modulation during acute pancreatitis.

Item Type: Article
Uncontrolled Keywords: acute pancreatitis, monocytes, immunity, inflammation, animal models, lipotoxicity, obesity, hypertriglyceridemia
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User: Symplectic Admin
Date Deposited: 08 Mar 2023 10:57
Last Modified: 08 Mar 2023 10:58
DOI: 10.3389/fimmu.2022.1062849
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