Botulinum toxin for the treatment of strabismus.

Bort-Martí, Angeles R, Rowe, Fiona J ORCID: 0000-0001-9210-9131, Ruiz Sifre, Laura, Ng, Sueko M, Bort-Martí, Sylvia and Ruiz Garcia, Vicente (2023) Botulinum toxin for the treatment of strabismus. The Cochrane database of systematic reviews, 3 (3). CD006499-CD006499. ISSN 1469-493X, 1469-493X

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Abstract

Background: The use of botulinum toxin as an investigative and treatment modality for strabismus is well reported in the medical literature. However, it is unclear how effective it is in comparison with other treatment options for strabismus. Objectives: The primary objective was to examine the efficacy of botulinum toxin therapy in the treatment of strabismus compared with alternative conservative or surgical treatment options. This review sought to ascertain those types of strabismus that particularly benefit from the use of botulinum toxin as a treatment option (such as small angle strabismus or strabismus with binocular potential, i.e. the potential to use both eyes together as a pair). The secondary objectives were to investigate the dose effect and complication rates associated with botulinum toxin. Search methods: We searched CENTRAL, MEDLINE, Embase, LILACS and three trials registers on 6 July 2022, together with reference checking to identify additional studies. We did not use any date or language restrictions in the electronic searches for trials. Selection criteria: We planned to include randomized controlled trials (RCTs) comparing botulinum toxin with strabismus surgery, botulinum toxin alternatives (i.e. bupivacaine) and conservative therapy such as orthoptic exercises, prisms, or lens therapy for people of any age with strabismus. All relevant RCTs identified in this update compared botulinum toxin with strabismus surgery. Data collection and analysis: We used standard methods expected by Cochrane and assessed the certainty of the body of evidence using GRADE.

Item Type:	Article
Uncontrolled Keywords:	Abducens Nerve Diseases [drug therapy], Botulinum Toxins, Type A [adverse effects] [therapeutic use], Neuromuscular Agents, [adverse effects] [therapeutic use], Randomized Controlled Trials as Topic, Strabismus [drug therapy] [surgery], Vision, Binocular, Adult, Child, Humans
Divisions:	Faculty of Health & Life Sciences Faculty of Health & Life Sciences > Inst. Population Health
Depositing User:	Symplectic Admin
Date Deposited:	17 Mar 2023 10:48
Last Modified:	28 Feb 2026 01:15
DOI:	10.1002/14651858.cd006499.pub5
Related Websites:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3169142
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