UroLift implants as surrogate fiducial markers for cone-beam CT-based prostate image-guided radiotherapy

Al-Balushi, Ahmed, Cain, Michelle, Reynolds, Phil and Bridge, Pete ORCID: 0000-0001-7704-9812 (2023) UroLift implants as surrogate fiducial markers for cone-beam CT-based prostate image-guided radiotherapy. JOURNAL OF RADIOTHERAPY IN PRACTICE, 22 (1). e85-. ISSN 1460-3969, 1467-1131

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Abstract

<jats:title>Abstract</jats:title> <jats:sec id="S1460396923000092_as1"> <jats:title>Introduction:</jats:title> <jats:p>UroLift implants are a novel treatment for the obstructive lower urinary tract symptoms arising from benign prostatic hyperplasia. This case study aimed to assess their effectiveness as fiducial marker (FM) surrogates in prostate image-guided radiotherapy (IGRT).</jats:p> </jats:sec> <jats:sec id="S1460396923000092_as2"> <jats:title>Method:</jats:title> <jats:p>Cone-beam CT images from a patient receiving prostate radiation therapy underwent manual alignment using UroLift implants and also prostate soft-tissue matching by five experienced therapeutic radiographers. The match values of both methods were compared using Bland–Altman analysis. All five observers were also asked to score the ease of matching using both approaches.</jats:p> </jats:sec> <jats:sec id="S1460396923000092_as3"> <jats:title>Results:</jats:title> <jats:p>The 95% mean level of agreement for the UroLift matches were within a 2-mm threshold in all dimensions. Comparison of UroLift and prostate matches had 95% limit of agreement values of −0·98 to 1·78, −0·58 to 0·49 and −1·83 to 1·04 mm in the vertical, longitudinal and lateral planes, respectively. All of the UroLift matches were rated as ‘very easy’ or ‘possible with little difficulty’ by the five observers.</jats:p> </jats:sec> <jats:sec id="S1460396923000092_as4"> <jats:title>Conclusion:</jats:title> <jats:p>A small difference between the CBCT UroLift and CBCT prostate match was found. It has been shown that IGRT to the prostate with the aid of the UroLift system implants and CBCT is feasible and can eliminate the need for FM implants. Wider evaluation in a large cohort is recommended.</jats:p> </jats:sec>

Item Type:	Article
Uncontrolled Keywords:	fiducial, IGRT, image registration, prostate, radiotherapy, UroLift
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Population Health Faculty of Health and Life Sciences > Institute of Population Health > School of Health Sciences
Depositing User:	Symplectic Admin
Date Deposited:	21 Mar 2023 08:26
Last Modified:	06 Dec 2024 21:28
DOI:	10.1017/S1460396923000092
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3169174