A global core outcome measurement set for snakebite clinical trials

Abouyannis, Michael, Esmail, Hanif, Hamaluba, Mainga, Ngama, Mwanajuma, Mwangudzah, Hope, Mumba, Noni, Yeri, Betty K, Mwalukore, Salim, Alphan, Hassan J, Aggarwal, Dinesh
et al (show 16 more authors) (2023) A global core outcome measurement set for snakebite clinical trials. LANCET GLOBAL HEALTH, 11 (2). E296-E300.

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Snakebite clinical trials have often used heterogeneous outcome measures and there is an urgent need for standardisation. A globally representative group of key stakeholders came together to reach consensus on a globally relevant set of core outcome measurements. Outcome domains and outcome measurement instruments were identified through searching the literature and a systematic review of snakebite clinical trials. Outcome domains were shortlisted by use of a questionnaire and consensus was reached among stakeholders and the patient group through facilitated discussions and voting. Five universal core outcome measures should be included in all future snakebite clinical trials-mortality, WHO disability assessment scale, patient-specific functional scale, acute allergic reaction by Brown criteria, and serum sickness by formal criteria. Additional syndrome-specific core outcome measures should be used depending on the biting species. This core outcome measurement set provides global standardisation, supports the priorities of patients and clinicians, enables meta-analysis, and is appropriate for use in low-income and middle-income settings.

Item Type: Article
Uncontrolled Keywords: Snakebite Global Core Outcome Set Study Group, Humans, Snake Bites, Treatment Outcome, Consensus, Clinical Trials as Topic, Global Health, Surveys and Questionnaires, Outcome Assessment, Health Care
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences
Depositing User: Symplectic Admin
Date Deposited: 18 Apr 2023 13:59
Last Modified: 31 Oct 2023 20:50
DOI: 10.1016/S2214-109X(22)00479-X
Open Access URL: https://doi.org/10.1016/S2214-109X(22)00479-X
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3169698