Ni(I)-Catalyzed Hydroxylation of Aryl Halides with Water under Thermal Catalysis

Yang, Liu, Yan, Yonggang, Cao, Ni, Hao, Jing, Li, Gang, Zhang, Wei, Cao, Rui, Wang, Chao, Xiao, Jianliang and Xue, Dong (2022) Ni(I)-Catalyzed Hydroxylation of Aryl Halides with Water under Thermal Catalysis. ORGANIC LETTERS, 24 (51). pp. 9431-9435.

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Official URL: http://dx.doi.org/10.1021/acs.orglett.2c03840

Abstract

A highly efficient hydroxylation of (hetero)aryl halides using water as a hydroxyl source via Ni catalysis promoted by PhSiH<sub>3</sub> under thermal catalysis is reported. This methodology provides a general procedure to obtain diverse multifunctional pharmaceutically phenols and polyphenols, some of which are proven challenging to be synthesized using literature methods. Mechanism studies demonstrated that the addition of PhSiH<sub>3</sub> led to the generation of active Ni(I) species, which catalyze the hydroxylation via a Ni(I)-Ni(III) pathway.

Item Type:	Article
Uncontrolled Keywords:	3402 Inorganic Chemistry, 34 Chemical Sciences
Divisions:	Faculty of Science and Engineering > School of Physical Sciences
Depositing User:	Symplectic Admin
Date Deposited:	19 Apr 2023 09:08
Last Modified:	22 Jun 2024 16:33
DOI:	10.1021/acs.orglett.2c03840
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3169719