Dop, Romy A 
ORCID: 0000-0002-3903-7236, Neill, Daniel R ORCID: 0000-0002-7911-8153 and Hasell, Tom ORCID: 0000-0003-4736-0604
(2023)
Sulfur-Polymer Nanoparticles: Preparation and Antibacterial Activity.
ACS APPLIED MATERIALS & INTERFACES, 15 (17).
pp. 20822-20832.
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Abstract
High sulfur content polymers prepared by inverse vulcanization have many reported potential applications, including as novel antimicrobial materials. High sulfur content polymers usually have limited water-solubility and dispersibility due to their hydrophobic nature, which could limit the development of their applications. Herein, we report the formulation of high sulfur content polymeric nanoparticles by a nanoprecipitation and emulsion-based method. High sulfur content polymeric nanoparticles were found to have an inhibitory effect against important bacterial pathogens, including Gram-positive methicillin-resistant <i>Staphylococcus aureus</i> and Gram-negative <i>Pseudomonas aeruginosa</i>. Salt-stable particles were formulated with the addition of a surfactant, which did not inhibit the antibacterial activity of the polymeric particles. Furthermore, the polymeric nanoparticles were found to inhibit <i>S. aureus</i> biofilm formation and exhibited low cytotoxicity against mammalian liver cells. Interaction of the polymeric particles with cellular thiols could be a potential mechanism of action against bacterial cells, as demonstrated by reaction with cysteine as a model thiol. The findings presented demonstrate methods of preparing aqueous dispersions of high sulfur content polymeric nanoparticles that could have useful biological applications.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | inverse vulcanization, sulfur, polysulfides, antibacterial, biofilm inhibition, nanoparticles |
| Divisions: | Faculty of Health and Life Sciences Faculty of Science and Engineering > School of Physical Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 20 Apr 2023 14:59 |
| Last Modified: | 29 May 2023 20:37 |
| DOI: | 10.1021/acsami.3c03826 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3169807 |
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