Ribosome stoichiometry: from form to function.

Emmott, Edward P ORCID: 0000-0002-3239-8178, Jovanovic, Marko and Slavov, Nikolai (2018) Ribosome stoichiometry: from form to function. Trends in Biochemical Sciences. ISSN 0167-7640

Access the full-text of this item by clicking on the Open Access link.

Abstract

The existence of eukaryotic ribosomes with distinct ribosomal protein (RP) stoichiometry and regulatory roles in protein synthesis been speculated for over sixty years. Recent advances in mass spectrometry and high throughput analysis have begun to identify and characterize distinct ribosome stoichiometry in yeast or mammalian systems. In addition to RP stoichiometry, ribosomes play host to a vast array of protein modifications, effectively expanding the number of human RPs from 80 to many thousands of distinct proteoforms. Is it possible these proteoforms combine to function as a ‘ribosome code’ to tune protein synthesis? We outline the specific benefits that translational regulation by specialized ribosomes can offer and discuss the means and methodologies available to correlate and characterize RP stoichiometry with function. We highlight previous research with a focus on formulating hypotheses that can guide future experiments and crack the ‘ribosome code’.

Item Type:	Article
Uncontrolled Keywords:	3101 Biochemistry and Cell Biology, 31 Biological Sciences, Genetics, 1.1 Normal biological development and functioning
Divisions:	Faculty of Health & Life Sciences Faculty of Health & Life Sciences > Inst. Systems, Molec & Integrative Biology > Inst. Systems, Molec & Integrative Biology
Depositing User:	Symplectic Admin
Date Deposited:	24 Apr 2023 07:29
Last Modified:	07 Dec 2024 19:40
DOI:	10.1016/j.tibs.2018.10.009
Open Access URL:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC63407...
Related Websites:	Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3169894
Disclaimer:	The University of Liverpool is not responsible for content contained on other websites from links within repository metadata. Please contact us if you notice anything that appears incorrect or inappropriate.