Hedrich, CM 
ORCID: 0000-0002-1295-6179, Beresford, MW ORCID: 0000-0002-5400-9911, Dedeoglu, F, Hahn, G, Hofmann, SR, Jansson, AF, Laxer, RM, Miettunen, P, Morbach, H, Pain, CE ORCID: 0000-0003-4965-3259 et al (show 8 more authors)
(2023)
Gathering expert consensus to inform a proposed trial in chronic nonbacterial osteomyelitis (CNO).
CLINICAL IMMUNOLOGY, 251.
109344-.
ISSN 1521-6616, 1521-7035
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Abstract
Chronic nonbacterial osteomyelitis (CNO) is an autoinflammatory bone disease that primarily affects children and adolescents. CNO is associated with pain, bone swelling, deformity, and fractures. Its pathophysiology is characterized by increased inflammasome assembly and imbalanced expression of cytokines. Treatment is currently based on personal experience, case series and resulting expert recommendations. Randomized controlled trials (RCTs) have not been initiated because of the rarity of CNO, expired patent protection of some medications, and the absence of agreed outcome measures. An international group of fourteen CNO experts and two patient/parent representatives was assembled to generate consensus to inform and conduct future RCTs. The exercise delivered consensus inclusion and exclusion criteria, patent protected (excludes TNF inhibitors) treatments of immediate interest (biological DMARDs targeting IL-1 and IL-17), primary (improvement of pain; physician global assessment) and secondary endpoints (improved MRI; improved PedCNO score which includes physician and patient global scores) for future RCTs in CNO.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CNO, CRMO, Treatment, Trial, Study, Osteomyelitis, Consensus, Outcome |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences Faculty of Health and Life Sciences > Clinical Directorate |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 04 May 2023 15:41 |
| Last Modified: | 06 Dec 2024 18:22 |
| DOI: | 10.1016/j.clim.2023.109344 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3170182 |
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