Investigating association between inflammatory bowel disease and rotavirus vaccination in a paediatric cohort in the UK

Flatt, Aidan, Inns, Thomas, Fleming, Kate M ORCID: 0000-0002-6572-5016, Iturriza-Gomara, Miren and Hungerford, Daniel ORCID: 0000-0002-9770-0163
(2023) Investigating association between inflammatory bowel disease and rotavirus vaccination in a paediatric cohort in the UK. EPIDEMIOLOGY AND INFECTION, 151. e103-.

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In the UK, the incidence and prevalence of inflammatory bowel disease (IBD) is increasing in paediatric populations. Environmental factors including acute gastroenteritis episodes (AGE) may impact IBD development. Infant rotavirus vaccination has been shown to significantly reduce AGE. This study aims to explore the association between vaccination with live oral rotavirus vaccines and IBD development. A population-based cohort study was used, analysing primary care data from the Clinical Practice Research Datalink Aurum. Participants included children born in the UK from 2010 to 2015, followed from a minimum of 6 months old to a maximum of 7 years old. The primary outcome was IBD, and the primary exposure was rotavirus vaccination. Cox regression analysis with random intercepts for general practices was undertaken, with adjustment for potential confounding factors. In a cohort of 907,477 children, IBD was recorded for 96 participants with an incidence rate of 2.1 per 100,000 person-years at risk. The univariable analysis hazard ratio (HR) for rotavirus vaccination was 1.45 (95% confidence interval (CI) 0.93-2.28). Adjustment in the multivariable model attenuated the HR to 1.19 (95% CI 0.53-2.69). This study shows no statistically significant association between rotavirus vaccination and development of IBD. However, it provides further evidence for the safety of live rotavirus vaccination.

Item Type: Article
Uncontrolled Keywords: Crohn's disease, infectious disease, inflammatory bowel disease, paediatric, rotavirus vaccine, survival analysis, ulcerative colitis, vaccine safety
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences
Depositing User: Symplectic Admin
Date Deposited: 06 Jun 2023 07:44
Last Modified: 27 Jul 2023 01:01
DOI: 10.1017/S0950268823000936
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