Casey, S, Carter, M, Looney, AM, Livingstone, V, Moloney, G, O'Keeffe, GW, Taylor, RS, Kenny, LC 
ORCID: 0000-0002-9011-759X, McCarthy, FP, McCowan, LME et al (show 2 more authors)
(2022)
Maternal Mid-Gestation Cytokine Dysregulation in Mothers of Children with Autism Spectrum Disorder.
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS, 52 (9).
pp. 3919-3932.
ISSN 0162-3257, 1573-3432
|
PDF
Maternal Mid-Gestation Cytokine Dysregulation in Mothers of Children with Autism Spectrum Disorder.pdf - Open Access published version Download (1MB) | Preview |
Abstract
Autism spectrum disorder (ASD) is a developmental disorder characterised by deficits in social interactions and communication, with stereotypical and repetitive behaviours. Recent evidence suggests that maternal immune dysregulation may predispose offspring to ASD. Independent samples t-tests revealed downregulation of IL-17A concentrations in cases, when compared to controls, at both 15 weeks (p = 0.02), and 20 weeks (p = 0.02), which persisted at 20 weeks following adjustment for confounding variables. This adds to the growing body of evidence that maternal immune regulation may play a role in foetal neurodevelopment.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | IL-17A, Autism spectrum disorder, Cytokine, Inflammation, Maternal immune activation |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 06 Jul 2023 13:51 |
| Last Modified: | 07 Dec 2024 23:21 |
| DOI: | 10.1007/s10803-021-05271-7 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3171489 |
Altmetric
Altmetric
