C. elegans dkf-1 (Protein Kinase D1) mutants have age-dependent defects in locomotion and neuromuscular transmission.

Johnson, James R and Barclay, Jeff W ORCID: 0000-0003-4320-2094 (2023) C. elegans dkf-1 (Protein Kinase D1) mutants have age-dependent defects in locomotion and neuromuscular transmission. microPublication biology, 2023. 10.17912/micropub.biology.000800-. ISSN 2578-9430, 2578-9430

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Abstract

Changes in neuronal function that occur with age are an area of increasing importance. A potential significant contributor to age-dependent decline may be alterations to neurotransmitter release. Protein kinases, such as Protein Kinase C and Protein Kinase A, are well characterised modulators of neuronal function and neurotransmission. Protein Kinase D (PRKD) is a serine/threonine kinase whose role in neurons is less well characterised. Here we report that mutations in the C. elegans PRKD homolog, dkf-1 , show an acceleration in age-dependent decline of locomotion rate and an alteration to age-dependent changes in aldicarb sensitivity. These effects could be explained by a pre- or post-synaptic function of the protein kinase as the animal ages.

Item Type:	Article
Uncontrolled Keywords:	3101 Biochemistry and Cell Biology, 31 Biological Sciences, Aging, Neurosciences, Genetics, 1.1 Normal biological development and functioning, Neurological
Divisions:	Faculty of Health & Life Sciences Faculty of Health & Life Sciences > Inst. Systems, Molec & Integrative Biology > Inst. Systems, Molec & Integrative Biology
Depositing User:	Symplectic Admin
Date Deposited:	06 Jul 2023 15:49
Last Modified:	20 Dec 2025 18:56
DOI:	10.17912/micropub.biology.000800
Related Websites:	Author
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3171511
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