Pang, Michelle D, Bastings, Jacco JAJ, Op den Kamp-Bruls, Yvonne MH, Harrold, Joanne A 
ORCID: 0000-0002-0899-4586, Kjolbaek, Louise, Halford, Jason CG ORCID: 0000-0003-1629-3189, Adam, Tanja CM, Raben, Anne, Schrauwen-Hinderling, Vera B, Goossens, Gijs H et al (show 1 more authors)
(2023)
The effect of weight loss on whole-body and tissue-specific insulin sensitivity and hepatic lipid content and composition: SWEET substudy.
OBESITY, 31 (7).
pp. 1745-1754.
Abstract
<h4>Objective</h4>This study (1) investigated the effect of weight loss on whole-body and tissue-specific insulin sensitivity and on intrahepatic lipid (IHL) content and composition and (2) investigated the association between weight-loss-induced changes in insulin sensitivity and IHL content in individuals with overweight or obesity.<h4>Methods</h4>In this secondary analysis of the European SWEET project, 50 adults (age 18-65 years) with overweight or obesity (BMI ≥ 25 kg/m<sup>2</sup> ) followed a low-energy diet (LED) for 2 months. At baseline and after the LED, body composition (dual-energy x-ray absorptiometry), IHL content and composition (proton magnetic resonance spectroscopy), whole-body insulin sensitivity (Matsuda index), muscle insulin sensitivity index (MISI), and hepatic insulin resistance index (HIRI) were determined (7-point oral glucose tolerance test).<h4>Results</h4>The LED reduced body weight (p < 0.001). This was accompanied by increased Matsuda index and reduced HIRI (both p < 0.001) but no change in MISI (p = 0.260). Weight loss decreased IHL content (mean [SEM], 3.9% [0.7%] vs. 1.6% [0.5%], p < 0.001) and the hepatic saturated fatty acid fraction (41.0% [1.5%] vs. 36.6% [1.9%], p = 0.039). The reduced IHL content was associated with an improvement in HIRI (r = 0.402, p = 0.025).<h4>Conclusions</h4>Weight loss decreased IHL content and the hepatic saturated fatty acid fraction. The decrease in IHL content was associated with weight-loss-induced improvement in hepatic insulin sensitivity in individuals with overweight or obesity.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Liver, Humans, Insulin Resistance, Obesity, Weight Loss, Insulin, Lipids, Fatty Acids, Adolescent, Adult, Aged, Middle Aged, Overweight, Young Adult |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Population Health |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 11 Jul 2023 12:43 |
| Last Modified: | 23 Aug 2023 06:22 |
| DOI: | 10.1002/oby.23773 |
| Open Access URL: | https://doi.org/10.1002/oby.23773 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3171617 |
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