Potential Impact of Long-Acting Products on the Control of Tuberculosis: Preclinical Advancements and Translational Tools in Preventive Treatment

Ammerman, Nicole C, Nuermberger, Eric L, Owen, Andrew ORCID: 0000-0002-9819-7651, Rannard, Steve P ORCID: 0000-0002-6946-1097, Meyers, Caren Freel and Swindells, Susan (2022) Potential Impact of Long-Acting Products on the Control of Tuberculosis: Preclinical Advancements and Translational Tools in Preventive Treatment CLINICAL INFECTIOUS DISEASES, 75 (4 Supp). S510-S516. ISSN 1058-4838, 1537-6591

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Abstract

A key component of global tuberculosis (TB) control is the treatment of latent TB infection. The use of long-acting technologies to administer TB preventive treatment has the potential to significantly improve the delivery and impact of this important public health intervention. For example, an ideal long-acting treatment could consist of a single dose that could be administered in the clinic (ie, a “1-shot cure” for latent TB). Interest in long-acting formulations for TB preventive therapy has gained considerable traction in recent years. This article presents an overview of the specific considerations and current preclinical advancements relevant for the development of long-acting technologies of TB drugs for treatment of latent infection, including attributes of target product profiles, suitability of drugs for long-acting formulations, ongoing research efforts, and translation to clinical studies.

Item Type:	Article
Uncontrolled Keywords:	latent tuberculosis infection, long-acting, tuberculosis, tuberculosis preventive treatment
Divisions:	Faculty of Health & Life Sciences Faculty of Health & Life Sciences > Inst. Systems, Molec & Integrative Biology > Inst. Systems, Molec & Integrative Biology Faculty of Science & Engineering > School of Physical Sciences
Depositing User:	Symplectic Admin
Date Deposited:	29 Sep 2023 15:53
Last Modified:	24 Jan 2026 03:57
DOI:	10.1093/cid/ciac672
Open Access URL:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10200...
Related Websites:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3172014
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