Modular synthesis of bicyclic twisted amides and anilines

Hindle, Alexandra, Baj, Krzysztof, Iggo, Jonathan A ORCID: 0000-0001-8070-1226, Cox, Daniel J, Pask, Christopher M, Nelson, Adam and Marsden, Stephen P
(2023) Modular synthesis of bicyclic twisted amides and anilines. CHEMICAL COMMUNICATIONS, 59 (41). pp. 6239-6242.

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Bridged amides and anilines display interesting properties owing to perturbation of conjugation of the nitrogen lone-pair with the adjacent π-system. A convergent approach to diazabicyclic scaffolds which contain either twisted amides or anilines is described, based on the photocatalysed hydroamination of cyclic enecarbamates and subsequent cyclisation. The modular nature of the synthesis allows for variation of the degree of 'twist' and hence the properties of the amides and anilines.

Item Type: Article
Divisions: Faculty of Science and Engineering > School of Physical Sciences
Depositing User: Symplectic Admin
Date Deposited: 28 Sep 2023 09:34
Last Modified: 28 Sep 2023 09:35
DOI: 10.1039/d3cc01470c
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