Turner, Simone, Khan, M Asad, Putrino, David, Woodcock, Ashley, Kell, Douglas B ORCID: 0000-0001-5838-7963 and Pretorius, Etheresia
(2023)
Long COVID: pathophysiological factors and abnormalities of coagulation.
TRENDS IN ENDOCRINOLOGY AND METABOLISM, 34 (6).
pp. 321-344.
ISSN 1043-2760, 1879-3061
Abstract
Acute COVID-19 infection is followed by prolonged symptoms in approximately one in ten cases: known as Long COVID. The disease affects ~65 million individuals worldwide. Many pathophysiological processes appear to underlie Long COVID, including viral factors (persistence, reactivation, and bacteriophagic action of SARS CoV-2); host factors (chronic inflammation, metabolic and endocrine dysregulation, immune dysregulation, and autoimmunity); and downstream impacts (tissue damage from the initial infection, tissue hypoxia, host dysbiosis, and autonomic nervous system dysfunction). These mechanisms culminate in the long-term persistence of the disorder characterized by a thrombotic endothelialitis, endothelial inflammation, hyperactivated platelets, and fibrinaloid microclots. These abnormalities of blood vessels and coagulation affect every organ system and represent a unifying pathway for the various symptoms of Long COVID.
Item Type: | Article |
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Uncontrolled Keywords: | Humans, Thrombosis, Inflammation, COVID-19, SARS-CoV-2, Post-Acute COVID-19 Syndrome |
Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology |
Depositing User: | Symplectic Admin |
Date Deposited: | 02 Oct 2023 09:31 |
Last Modified: | 06 Dec 2024 17:55 |
DOI: | 10.1016/j.tem.2023.03.002 |
Open Access URL: | https://doi.org/10.1016/j.tem.2023.03.002 |
Related URLs: | |
URI: | https://livrepository.liverpool.ac.uk/id/eprint/3173277 |