James Antoine, Daniel
(2009)
Chemical and molecular markers of hepatic drug bioactivation, apoptosis and necrosis.
PhD thesis, University of Liverpool.
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Abstract
Hepatotoxicity represents one of the most prevalent drug-induced adverse effects seen in the clinic and is a major cause of attrition of new chemical entities in development. Some adverse drug reactions are associated with metabolic activation to a chemically reactive intermediate. The hepatotoxicity associated with acetaminophen (APAP; paracetamol) and furosemide (FS) in mice is initiated by the formation of a reactive metabolite which has been well characterised. APAP hepatotoxicity is a major clinical problem, and with FS represents an important tool to investigate mechanisms of drug induced liver injury (DILI) in animal models.
| Item Type: | Thesis (PhD) |
|---|---|
| Depositing User: | Symplectic Admin |
| Date Deposited: | 20 Oct 2023 09:24 |
| Last Modified: | 20 Oct 2023 09:48 |
| DOI: | 10.17638/03174378 |
| Copyright Statement: | Copyright © and Moral Rights for this thesis and any accompanying data (where applicable) are retained by the author and/or other copyright owners. A copy can be downloaded for personal non-commercial research or study, without prior permission or charge |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3174378 |
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