Relationship between the concentration of ergothioneine in plasma and the likelihood of developing pre-eclampsia

Kenny, Louise ORCID: 0000-0002-9011-759X, Brown, Leslie, Ortea, Paloma, Tuytten, Robin ORCID: 0000-0002-8734-7335 and Kell, Douglas ORCID: 0000-0001-5838-7963 (2022) Relationship between the concentration of ergothioneine in plasma and the likelihood of developing pre-eclampsia. [Preprint]

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Abstract

Ergothioneine, an antioxidant nutraceutical mainly at present derived from the dietary intake of mushrooms, has been suggested as a preventive for pre-eclampsia. We analysed early pregnancy samples for a cohort of 432 first time mothers as part of the Screening for Endpoints in Pregnancy (SCOPE, European branch) project to determine the concentration of ergothioneine in their plasma. There was a weak association between the ergothioneine levels and maternal age, but none for BMI. Of these 432 women, 97 went on to develop pre-term (23) or term (74) pre-eclampsia. If a threshold was set at the 90 th percentile of the reference range in the control population (≥ 462 ng/mL), only one of these 97 women (1%) developed pre-eclampsia, versus 97/432 (22.5%) whose ergothioneine level was below this threshold. One possible interpretation of these findings, consistent with previous experiments in a reduced uterine perfusion model in rats, is that ergothioneine may indeed prove protective against pre-eclampsia in humans. An intervention study of some kind now seems warranted.

Item Type:	Preprint
Uncontrolled Keywords:	3215 Reproductive Medicine, 32 Biomedical and Clinical Sciences, Contraception/Reproduction, Women's Health, Prevention, 3 Good Health and Well Being
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User:	Symplectic Admin
Date Deposited:	25 Oct 2023 10:00
Last Modified:	25 Apr 2025 09:24
DOI:	10.1101/2022.12.19.22283617
Related Websites:	Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3176425