Trigeminal neuropathy presenting secondary to SARS-CoV-2 infection

O'Neill, Francis ORCID: 0000-0002-6009-1026, De Stefano, Gianfranco, Pridgeon, Mike, Bhargava, Deepti, Marshall, Anne ORCID: 0000-0002-2331-3750, Marshall, Andrew ORCID: 0000-0001-8273-7089 and Frank, Bernhard (2023) Trigeminal neuropathy presenting secondary to SARS-CoV-2 infection PAIN REPORTS, 8 (6). E1103-. ISSN 2471-2531, 2471-2531

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Abstract

Introduction:A 58-year-old woman presented to a multidisciplinary facial pain clinic in October 2021 complaining of a constant pain in the right side of her face since contracting coronavirus SARS-CoV-2 18 months earlier. The pain extending from the right temple down to her right cheek extraorally and including the maxillary teeth and right side of tongue intraorally. This was accompanied by anosmia, diplopia on lateral gaze, and dizziness.Methods:Clinical examination was supplemented with several neurophysiological tests to confirm the diagnosis including an MRI brain scan, quantitative sensory testing, electrophysiological blink reflex testing, corneal confocal microscopy, and pain and short-form anxiety and depression questionnaires.Results:Quantitative sensory testing showed unilateral loss of perception in thermal and mechanical sensibility and bilateral hyperalgesia indicating central sensitization. Bilateral corneal confocal microscopy showed an abnormally reduced corneal nerve fibre length on the right side. MRI, blink reflex, and masseter inhibitory testing findings were normal.Conclusion:This case study is the first case of trigeminal neuropathy related to SARS-CoV-2 infection reported in the literature. It also discusses the successful management of the patient's trigeminal neuropathic pain.

Item Type:	Article
Uncontrolled Keywords:	Neuropathic, Pain, Facial pain
Divisions:	Faculty of Health & Life Sciences Faculty of Health & Life Sciences > Inst. Life Courses & Medical Sciences Faculty of Health & Life Sciences > Inst. Life Courses & Medical Sciences > School of Dentistry Faculty of Health & Life Sciences > Inst. Life Courses & Medical Sciences > School of Medicine
Depositing User:	Symplectic Admin
Date Deposited:	02 Nov 2023 10:37
Last Modified:	22 May 2026 19:34
DOI:	10.1097/PR9.0000000000001103
Related Websites:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3176492
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