Sengupta, Dhriti ORCID: 0000-0001-6315-7804, Choudhury, Ananyo ORCID: 0000-0001-8225-9531, Fortes-Lima, Cesar ORCID: 0000-0002-8972-3357, Fortes-Lima, Cesar ORCID: 0000-0002-9310-5009, Aron, Shaun ORCID: 0000-0001-6200-0485, Whitelaw, Gavin ORCID: 0000-0003-1638-7222, Bostoen, Koen ORCID: 0000-0003-2284-6165, Gunnink, Hilde, Chousou-Polydouri, Natalia, Delius, Peter et al (show 10 more authors)
(2021)
Genetic substructure and complex demographic history of South African Bantu speakers.
Nature communications, 12 (1).
2080-.
ISSN 2041-1723, 2041-1723
Abstract
South Eastern Bantu-speaking (SEB) groups constitute more than 80% of the population in South Africa. Despite clear linguistic and geographic diversity, the genetic differences between these groups have not been systematically investigated. Based on genome-wide data of over 5000 individuals, representing eight major SEB groups, we provide strong evidence for fine-scale population structure that broadly aligns with geographic distribution and is also congruent with linguistic phylogeny (separation of Nguni, Sotho-Tswana and Tsonga speakers). Although differential Khoe-San admixture plays a key role, the structure persists after Khoe-San ancestry-masking. The timing of admixture, levels of sex-biased gene flow and population size dynamics also highlight differences in the demographic histories of individual groups. The comparisons with five Iron Age farmer genomes further support genetic continuity over ~400 years in certain regions of the country. Simulated trait genome-wide association studies further show that the observed population structure could have major implications for biomedical genomics research in South Africa.
Item Type: | Article |
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Uncontrolled Keywords: | AWI-Gen Study, H3Africa Consortium, Chromosomes, Human, Y, Humans, Language, Genetics, Population, Genomics, Demography, Phylogeny, Gene Frequency, Haplotypes, Geography, Linguistics, South Africa, Female, Male, Gene Flow, Genetic Variation, Genome-Wide Association Study, Ethnicity, Black People |
Divisions: | Faculty of Humanities and Social Sciences > School of Histories, Languages and Cultures |
Depositing User: | Symplectic Admin |
Date Deposited: | 02 Nov 2023 09:18 |
Last Modified: | 06 Dec 2024 17:03 |
DOI: | 10.1038/s41467-021-22207-y |
Open Access URL: | http://www.nature.com/articles/s41467-021-22207-y#... |
Related URLs: | |
URI: | https://livrepository.liverpool.ac.uk/id/eprint/3176532 |