A multi-country analysis of COVID-19 hospitalizations by vaccination status

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Gonçalves, BP, Jassat, W, Baruch, J, Hashmi, M, Rojek, A, Dasgupta, A, Martin-Loeches, I, Reyes, LF, Piubelli, C, Citarella, BW et al (show 89 more authors) , Kartsonaki, C, Lefèvre, B, López Revilla, JW, Lunn, M, Harrison, EM, Kraemer, MUG, Shrapnel, S, Horby, P, Bisoffi, Z, Olliaro, PL, Merson, L, Abdukahil, SA, Jabal, KA, Salah, NA, Airlangga, E, Hssain, AA, Akwani, C, Al Qasim, E, Alberti, A, Aldabbourosama, O, Alessi, M, Alex, B, Al-Fares, A, Aliudin, J, Alkahlout, M, Almasri, L, Al-Saba'a, Y, Alves, R, Cabrita, JA, Amaral, M, Ampaw, P, Anchan, AJ, Angheben, A, Arabi, Y, Arcadipane, A, Archambault, P, Arenz, L, Arora, R, Ashley, EA, Atique, A, Atlowly, M, Bach, B, Baillie, JK, Baird, JK, Balan, V, Barbalho, R, Barbosa, NY, Barclay, WS, Barnikel, M, Beer, N, Begum, H, Bellemare, D, Beltrame, A, Bertoli, G, Bianco, C, Humaid, FB, Bitton, J, Blier, C, Bogaert, D, Borges, D, Bouhmani, D, Bounphiengsy, T, Bountthasavong, L, Klerk, BBD, Monteiro, FB, Brazzi, L, Buchtele, N, Buonsenso, D, Burrell, A, Bustos, IG, Caceres, E, Garcês, RC, Campisi, J, Canepa, C, Caoili, J, Cardellino, CS, Cardoso, F, Cardoso, F, Cardoso, S, Carney, G, Carrier, FM, Carson, G, Cascão, M, Casimiro, J, Castañeda, S, Castanheira, N, Cattaneo, P, Cavalin, R and Cavayas, A (2023) A multi-country analysis of COVID-19 hospitalizations by vaccination status Med, 4 (11). 797-812.e2. ISSN 2666-6359, 2666-6340

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Abstract

Background: Individuals vaccinated against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), when infected, can still develop disease that requires hospitalization. It remains unclear whether these patients differ from hospitalized unvaccinated patients with regard to presentation, coexisting comorbidities, and outcomes. Methods: Here, we use data from an international consortium to study this question and assess whether differences between these groups are context specific. Data from 83,163 hospitalized COVID-19 patients (34,843 vaccinated, 48,320 unvaccinated) from 38 countries were analyzed. Findings: While typical symptoms were more often reported in unvaccinated patients, comorbidities, including some associated with worse prognosis in previous studies, were more common in vaccinated patients. Considerable between-country variation in both in-hospital fatality risk and vaccinated-versus-unvaccinated difference in this outcome was observed. Conclusions: These findings will inform allocation of healthcare resources in future surges as well as design of longer-term international studies to characterize changes in clinical profile of hospitalized COVID-19 patients related to vaccination history. Funding: This work was made possible by the UK Foreign, Commonwealth and Development Office and Wellcome (215091/Z/18/Z, 222410/Z/21/Z, 225288/Z/22/Z, and 220757/Z/20/Z); the Bill & Melinda Gates Foundation (OPP1209135); and the philanthropic support of the donors to the University of Oxford's COVID-19 Research Response Fund (0009109). Additional funders are listed in the “acknowledgments” section.

Item Type:	Article
Uncontrolled Keywords:	ISARIC Clinical Characterisation Group, Humans, Vaccination, Hospitalization, Hospitals, COVID-19, SARS-CoV-2
Divisions:	Faculty of Health & Life Sciences Faculty of Health & Life Sciences > Inst. Infection, Vet & Ecological Sciences
Depositing User:	Symplectic Admin
Date Deposited:	17 Nov 2023 11:21
Last Modified:	22 Jan 2026 03:54
DOI:	10.1016/j.medj.2023.08.005
Open Access URL:	https://doi.org/10.1016/j.medj.2023.08.005
Related Websites:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3176854
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