A multi-country analysis of COVID-19 hospitalizations by vaccination status.


Gonçalves, Bronner P, Jassat, Waasila, Baruch, Joaquín, Hashmi, Madiha, Rojek, Amanda, Dasgupta, Abhishek, Martin-Loeches, Ignacio, Reyes, Luis Felipe, Piubelli, Chiara, Citarella, Barbara Wanjiru ORCID: 0000-0001-8968-0708 et al (show 12 more authors) (2023) A multi-country analysis of COVID-19 hospitalizations by vaccination status. Med (New York, N.Y.), 4 (11). 797-812.e2.

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Abstract

<h4>Background</h4>Individuals vaccinated against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), when infected, can still develop disease that requires hospitalization. It remains unclear whether these patients differ from hospitalized unvaccinated patients with regard to presentation, coexisting comorbidities, and outcomes.<h4>Methods</h4>Here, we use data from an international consortium to study this question and assess whether differences between these groups are context specific. Data from 83,163 hospitalized COVID-19 patients (34,843 vaccinated, 48,320 unvaccinated) from 38 countries were analyzed.<h4>Findings</h4>While typical symptoms were more often reported in unvaccinated patients, comorbidities, including some associated with worse prognosis in previous studies, were more common in vaccinated patients. Considerable between-country variation in both in-hospital fatality risk and vaccinated-versus-unvaccinated difference in this outcome was observed.<h4>Conclusions</h4>These findings will inform allocation of healthcare resources in future surges as well as design of longer-term international studies to characterize changes in clinical profile of hospitalized COVID-19 patients related to vaccination history.<h4>Funding</h4>This work was made possible by the UK Foreign, Commonwealth and Development Office and Wellcome (215091/Z/18/Z, 222410/Z/21/Z, 225288/Z/22/Z, and 220757/Z/20/Z); the Bill & Melinda Gates Foundation (OPP1209135); and the philanthropic support of the donors to the University of Oxford's COVID-19 Research Response Fund (0009109). Additional funders are listed in the "acknowledgments" section.

Item Type: Article
Uncontrolled Keywords: ISARIC Clinical Characterisation Group, Humans, Vaccination, Hospitalization, Hospitals, COVID-19, SARS-CoV-2
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences
Depositing User: Symplectic Admin
Date Deposited: 17 Nov 2023 11:21
Last Modified: 20 Mar 2024 16:41
DOI: 10.1016/j.medj.2023.08.005
Open Access URL: https://doi.org/10.1016/j.medj.2023.08.005
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3176854
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