Ex vivo transdermal delivery of 3H-labelled atovaquone solid drug nanoparticles: a comparison of topical, intradermal injection and microneedle assisted administration

Morris, Sam, Long, Mark, Savage, Alison, Owen, Andrew, Rannard, Steve and Cauldbeck, Helen (2023) Ex vivo transdermal delivery of 3H-labelled atovaquone solid drug nanoparticles: a comparison of topical, intradermal injection and microneedle assisted administration. Nanoscale Advances, 5 (23). pp. 6400-6404.

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Official URL: http://dx.doi.org/10.1039/d3na00454f

Abstract

<jats:p> <jats:italic>Ex vivo</jats:italic> transdermal permeation and deposition of atovaquone solid drug nanoparticles. Topical administration exhibited limited penetration, intradermal injection delivered a burst release and the microneedle assisted route offered sustained delivery.</jats:p>

Item Type:	Article
Uncontrolled Keywords:	3403 Macromolecular and Materials Chemistry, 34 Chemical Sciences, 40 Engineering, 4016 Materials Engineering, 4018 Nanotechnology, Bioengineering, 5.1 Pharmaceuticals, 3 Good Health and Well Being
Divisions:	Faculty of Health and Life Sciences Faculty of Science and Engineering > School of Physical Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User:	Symplectic Admin
Date Deposited:	20 Nov 2023 16:07
Last Modified:	18 Jul 2024 16:45
DOI:	10.1039/d3na00454f
Open Access URL:	https://doi.org/10.1039/D3NA00454F
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3176917