Balanza, N 
ORCID: 0000-0002-3581-0383, Francis, CK, Crowley, VM ORCID: 0000-0002-2593-1130, Weckman, AM ORCID: 0000-0002-2200-4008, Zhong, K, Baro, B ORCID: 0000-0001-7780-1744, Varo, R ORCID: 0000-0003-4282-5572, Bassat, Q ORCID: 0000-0003-0875-7596, Kain, KC ORCID: 0000-0001-6068-1272, Mayor, A et al (show 16 more authors)
(2024)
Neurofilament Light Chain as a Biomarker of Neuronal Damage in Children With Malaria
Journal of Infectious Diseases, 229 (1).
pp. 183-188.
ISSN 0022-1899, 1537-6613
Abstract
Malaria can cause brain injury. Neurofilament light chain (NfL) is a biomarker of neuronal damage. Here we examined longitudinal plasma NfL levels in children aged 1-12 years with uncomplicated and severe malaria from Mozambique. NfL levels were similar in all malaria cases at hospital admission. However, levels increased over time and the increment was significantly higher in severe malaria cases with neurological manifestations (ie, coma, impaired consciousness, or repeated seizures). NfL may be useful to identify and quantify brain injury in malaria.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Rosiglitazone Adjunctive Therapy for Severe Malaria in Children (ROSI) Study Group, Intermediate Filaments, Humans, Malaria, Brain Injuries, Seizures, Neurofilament Proteins, Child, Biomarkers |
| Divisions: | Faculty of Health & Life Sciences Faculty of Health & Life Sciences > Inst. Life Courses & Medical Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 06 Feb 2024 09:39 |
| Last Modified: | 24 Jan 2026 04:45 |
| DOI: | 10.1093/infdis/jiad373 |
| Open Access URL: | https://doi.org/10.1093/infdis/jiad373 |
| Related Websites: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3178424 |
| Disclaimer: | The University of Liverpool is not responsible for content contained on other websites from links within repository metadata. Please contact us if you notice anything that appears incorrect or inappropriate. |
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