Emerging variants of canine enteric coronavirus associated with seasonal outbreaks of severe canine gastroenteric disease

Collapse authors list.
Cunningham-Oakes, Edward ORCID: 0000-0003-0260-5508, Pilgrim, Jack ORCID: 0000-0002-2941-1482, Darby, Alistair ORCID: 0000-0002-3786-6209, Appleton, Charlotte, Jewell, Chris, Rowlingson, Barry, Cuartero, Carmen Tamayo, Newton, Richard, Sánchez-Vizcaíno, Fernando ORCID: 0000-0002-1655-8290, Fins, Ivo Salgueiro et al (show 9 more authors) , Brant, Bethaney ORCID: 0000-0003-1153-5054, Smith, Shirley, Penrice-Randal, Rebekah ORCID: 0000-0002-0653-2097, Clegg, Simon, Roberts, Ashley PE, Millson, Stefan, Pinchbeck, Gina ORCID: 0000-0002-5671-8623, Noble, P-J ORCID: 0000-0002-2275-2014 and Radford, Alan ORCID: 0000-0002-4590-1334 (2022) Emerging variants of canine enteric coronavirus associated with seasonal outbreaks of severe canine gastroenteric disease [Preprint]

PDF Emerging variants of canine enteric coronavirus associated with seasonal outbreaks of severe canine gastroenteric disease.pdf - Other Download (3MB) | Preview

Abstract

Canine enteric coronavirus (CECoV) variants have an emerging role in severe outbreaks of canine gastroenteritis. Here we used syndromic health data from a sentinel network of UK veterinary practices to identify an outbreak of severe canine gastroenteritis. Affected dogs frequently presented with vomiting, diarrhoea and inappetence. Data from sentinel diagnostic laboratories showed similar seasonal increases in CECoV diagnosis. Membrane glycoprotein (M) gene sequence analysis implied wide geographical circulation of a new CECoV variant. Whole genome sequencing suggested the main circulating 2022 variant was most closely related to one previously identified in 2020 with additional spike gene recombination; all variants were unrelated to CECoV-like viruses recently associated with human respiratory disease. Identifying factors that drive population-level evolution, and its implications for host protection and virulence, will be important to understand the emerging role of CECoV variants in canine and human health, and may act as a model for coronavirus population adaptation more widely.

Item Type:	Preprint
Uncontrolled Keywords:	3009 Veterinary Sciences, 30 Agricultural, Veterinary and Food Sciences, 31 Biological Sciences, Genetics, Emerging Infectious Diseases, Biotechnology, Digestive Diseases, Infectious Diseases, Biodefense, Infection, 3 Good Health and Well Being
Divisions:	Faculty of Health & Life Sciences Faculty of Health & Life Sciences > Inst. Infection, Vet & Ecological Sciences Faculty of Health & Life Sciences > Research & Impact Directorate
Depositing User:	Symplectic Admin
Date Deposited:	04 Mar 2024 09:20
Last Modified:	26 Feb 2026 19:49
DOI:	10.1101/2022.10.03.510536
Related Websites:	Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3179077
Disclaimer:	The University of Liverpool is not responsible for content contained on other websites from links within repository metadata. Please contact us if you notice anything that appears incorrect or inappropriate.