The MeshCODE to scale – Visualising synaptic binary information

Barnett, Samuel and Goult, Benjamin ORCID: 0000-0002-3438-2807
(2022) The MeshCODE to scale – Visualising synaptic binary information. [Preprint]

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The Mercator projection map of the world provides a useful, but distorted, view of the relative scale of countries. Current cellular models suffer from a similar distortion. Here, we undertook an in-depth structural analysis of the molecular dimensions in the cell’s computational machinery, the MeshCODE, that is assembled from a meshwork of binary switches in the scaffolding proteins talin and vinculin. Talin contains a series of force-dependent binary switches and each domain switching state introduces quantised step-changes in talin length on a micrometre scale. The average dendritic spine is 1 µm in diameter so this analysis identifies a plausible Gearbox-like mechanism for dynamic regulation of synaptic function, whereby the positioning of enzymes and substrates relative to each other, mechanically-encoded by the MeshCODE switch patterns, might control synaptic transmission. Based on biophysical rules and experimentally derived distances, this analysis yields a novel perspective on biological digital information.

Item Type: Preprint
Uncontrolled Keywords: 3101 Biochemistry and Cell Biology, 31 Biological Sciences, Bioengineering, 1.1 Normal biological development and functioning
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User: Symplectic Admin
Date Deposited: 13 Mar 2024 10:01
Last Modified: 19 Jul 2024 16:56
DOI: 10.1101/2022.06.16.496395
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