Chabronova, Alzbeta 
ORCID: 0000-0002-9733-444X, Holmes, Terri L, Hoang, Duc M, Denning, Chris, James, Victoria, Smith, James GW and Peffers, Mandy J ORCID: 0000-0001-6979-0440
(2024)
SnoRNAs in cardiovascular development, function, and disease.
Trends in molecular medicine, 30 (6).
S1471-4914(24)00059-5-S1471-4914(24)00059-5.
ISSN 1471-4914, 1471-499X
Abstract
Small nucleolar RNAs (snoRNAs) are emerging as important regulators of cardiovascular (patho)biology. Several roles of snoRNAs have recently been identified in heart development and congenital heart diseases, as well as their dynamic regulation in hypertrophic and dilated cardiomyopathies, coronary heart disease (CHD), myocardial infarction (MI), cardiac fibrosis, and heart failure. Furthermore, reports of changes in vesicular snoRNA expression and altered levels of circulating snoRNAs in response to cardiac stress suggest that snoRNAs also function in cardiac signaling and intercellular communication. In this review, we summarize and discuss key findings and outline the clinical potential of snoRNAs considering current challenges and gaps in the field of cardiovascular diseases (CVDs).
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Cardiovascular System, Animals, Humans, Cardiovascular Diseases, RNA, Small Nucleolar, Signal Transduction |
| Divisions: | Faculty of Health & Life Sciences Faculty of Health & Life Sciences > Inst. Life Courses & Medical Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 17 Apr 2024 10:05 |
| Last Modified: | 23 May 2026 08:38 |
| DOI: | 10.1016/j.molmed.2024.03.004 |
| Open Access URL: | https://doi.org/10.1016/j.molmed.2024.03.004 |
| Related Websites: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3180405 |
| Disclaimer: | The University of Liverpool is not responsible for content contained on other websites from links within repository metadata. Please contact us if you notice anything that appears incorrect or inappropriate. |
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